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Adenomatous Polyposis Coli (APC) (AA 1-433), (N-Term) antibody

Details for Product No. ABIN152091, Supplier: Login to see
Antigen
  • dp2
  • dp3
  • fap
  • fpc
  • xapc
  • dp2.5
  • AI047805
  • AU020952
  • AW124434
  • CC1
  • Min
  • mAPC
  • BTPS2
  • DP2
  • DP2.5
  • DP3
  • GS
  • PPP1R46
  • RATAPC
  • APC1
Alternatives
anti-Human Adenomatous Polyposis Coli antibody for Immunocytochemistry
Epitope
N-Term, AA 1-433
25
24
17
15
13
10
7
4
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
122
72
41
5
3
2
2
1
1
Host
Mouse
127
18
15
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
7
4
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
98
61
43
35
30
22
17
13
8
4
2
1
1
1
Supplier
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Immunogen Amino acids 1-433 N-terminal fragment of human APC (Adenomutons Polyposis Coli gene Chr 5q) fused to maltose binding protein.
Clone ALi 12-28
Isotype IgG1
Specificity This recognises the N-terminal region of the APC protein.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein A purified
Alternative Name APC / DP2.5 (APC Antibody Abstract)
Background This gene encodes a tumor suppressor protein that includes among its manyintracellular functions one of nuclear export. Defects in this gene cause familialadenomatous polyposis (FAP), an autosomal dominant pre-malignant disease thatusually progresses to malignancy. Disease-associated mutations tend to be clustered ina small region designated the mutation cluster region (MCR) and result in a truncatedprotein product. Alternate Names: anti-Adenomatous Polyposis Coli antibody, anti-APC antibody, anti-DP2 antibody,anti-DP2.5 antibody, anti-DP3 antibody, anti-FAP antibody, anti-FPC antibody, anti-GSantibody.
Gene Symbol: APC
Gene ID 324, 11789
Research Area Coagulation
Pathways WNT Signaling
Application Notes This antibody has been used routinely for Western blotting on colon cell line HCT116, SW480 and SW837 extracts.
Recommended dilutions: Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Frozen 1:10-1:2000, Immunoprecipitation 1:10-1:500, Western Blot 1:100-1:2000
Restrictions For Research Use only
Buffer PBS
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Product cited in: Abutaily, Collins, Roche: "Cadherins, catenins and APC in pleural malignant mesothelioma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 355-62, 2003 (PubMed).

Background publications Fodde, Kuipers, Rosenberg et al.: "Mutations in the APC tumour suppressor gene cause chromosomal instability." in: Nature cell biology, Vol. 3, Issue 4, pp. 433-8, 2001 (PubMed).