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Adenomatous Polyposis Coli (APC) (N-Term) antibody

Details for Product No. ABIN152091, Supplier: Log in to see
Antigen
  • dp2
  • dp3
  • fap
  • fpc
  • xapc
  • dp2.5
  • AI047805
  • AU020952
  • AW124434
  • CC1
  • Min
  • mAPC
  • BTPS2
  • DP2
  • DP2.5
  • DP3
  • GS
  • PPP1R46
  • RATAPC
  • APC1
  • adenomatous polyposis coli
  • adenomatous polyposis coli protein
  • adenomatosis polyposis coli
  • APC
  • apc
  • Smp_139190
  • Apc
Alternatives
anti-Human Adenomatous Polyposis Coli antibody for Immunocytochemistry
Epitope
N-Term
26
24
22
18
15
10
9
4
4
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
162
105
73
10
7
6
5
4
3
2
2
1
Host
Mouse
148
36
15
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
9
7
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
137
76
62
53
46
26
26
21
14
4
2
2
1
1
Options
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Immunogen Amino acids 1-433 N-terminal fragment of human APC (Adenomutons Polyposis Coli gene Chr 5q) fused to maltose binding protein.
Clone ALi 12-28
Isotype IgG1
Specificity This recognises the N-terminal region of the APC protein.
Purification Protein A purified
Alternative Name APC (APC Antibody Abstract)
Background Gene Symbol: APC
Gene ID 324
UniProt P25054
Research Area Cell Cycle, Cardiovascular, Coagulation, Transcription Factors, Wnt, Cardiogenesis
Pathways WNT Signaling, Stem Cell Maintenance
Application Notes Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500This antibody has been used routinely for Western blotting on colon cell line HCT116, SW480 and SW837 extracts.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.2 mg/mL
Buffer PBS
Buffer contains: No Preservative
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Product cited in: Abutaily, Collins, Roche: "Cadherins, catenins and APC in pleural malignant mesothelioma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 355-62, 2003 (PubMed).

Background publications Fodde, Kuipers, Rosenberg, Smits, Kielman, Gaspar, van Es, Breukel, Wiegant, Giles, Clevers: "Mutations in the APC tumour suppressor gene cause chromosomal instability." in: Nature cell biology, Vol. 3, Issue 4, pp. 433-8, 2001 (PubMed).