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Details for Product No. ABIN152091

Adenomatous Polyposis Coli (APC) antibody

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Synonyms BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, RATAPC, CC1, Min, mAPC, AI047805, AU020952, AW124434, dp2, dp3, fap, fpc, xapc, dp2.5
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN152091
Quantity 0.1 mg
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Immunogen Amino acids 1-433 N-terminal fragment of human APC (Adenomutons Polyposis Coligene Chr 5q) fused to maltose binding protein.
Clone ALi 12-28
Isotype IgG1
Specificity This antibody recognises the N-terminal region of the APC protein. Species Reactivity: Cross-reacts with Human. Does not cross-react with Mouse. Not yet tested in otherspecies. Localization: Cytoplasmic and Nuclear.
Cross-Reactivity Human
Purification Purified
Alternative Name APC / DP2.5
Background This gene encodes a tumor suppressor protein that includes among its manyintracellular functions one of nuclear export. Defects in this gene cause familialadenomatous polyposis (FAP), an autosomal dominant pre-malignant disease thatusually progresses to malignancy. Disease-associated mutations tend to be clustered ina small region designated the mutation cluster region (MCR) and result in a truncatedprotein product. Alternate Names: anti-Adenomatous Polyposis Coli antibody, anti-APC antibody, anti-DP2 antibody,anti-DP2.5 antibody, anti-DP3 antibody, anti-FAP antibody, anti-FPC antibody, anti-GSantibody.
Gene ID 324, 11789
Research Area Coagulation
Application Notes This antibody has been used routinely for Western blotting on colon cell line HCT116,SW480 and SW837 extracts.
Restrictions For Research Use only
Concentration 1.1 mg/ml
Buffer Phosphate buffered saline
Storage 4 °C
Fodde, Kuipers, Rosenberg et al.: "Mutations in the APC tumour suppressor gene cause chromosomal instability." in: Nature cell biology, Vol. 3, Issue 4, pp. 433-8, 2001 (PubMed).

Abutaily, Collins, Roche: "Cadherins, catenins and APC in pleural malignant mesothelioma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 355-62, 2003 (PubMed).

Alternatives for antigen "Adenomatous Polyposis Coli (APC)", type "Antibodies"
Hosts (72), (20), (16), (1)
Reactivities (87), (50), (32), (13), (12), (1), (1)
Applications (65), (37), (31), (26), (22), (20), (14), (11), (4), (4), (2), (2), (1)
Conjugates (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (18), (13), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)