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Details for Product No. ABIN152110

Keratin 19 (KRT19) antibody

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Antigen
Synonyms CK19, K19, K1CS, AI663979, EndoC, Krt-1.19, Krt1-19, Ka19, GK-19, k19, ck19, k1cs, krt9, krt15, MGC76282, MGC83069, KRT19, MGC154386, DKFZp469N0613
Reactivity
»Alternatives Human, Monkey, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN152110
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide derived from the C-terminal region of human cytokeratin 19. Unfortunately, the exact amino acid sequence is considered to be commerciallysensitive.
Specificity Species Reactivity: Human and mouse. Other species have not been tested. Localization: Cytoplasmic.
Cross-Reactivity Human, Mouse (Murine)
Purification Affinity Purified
Alternative Name Cytokeratin 19
Background This protein is a member of the keratin family. The keratins are intermediate filamentproteins responsible for the structural integrity of epithelial cells and are subdivided intocytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins whichare arranged in pairs of heterotypic keratin chains. Unlike its related family members,this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelialcells. It is specifically expressed in the periderm, the transiently superficial layer thatenvelopes the developing epidermis. Keratin 19 is not expressed in hepatocytes,therefore, antibody to keratin 19 is useful in the identification of liver metastasis. Thedegree of keratin 19 positivity in breast cancer distinguishes malignant from benigntumours. Keratin 19 is often co-expressed with keratin 7. Alternate Names: anti-ck19 antibody, anti-Cytokeratin 19 antibody, anti-k19 antibody, anti-k1cs antibody,anti-Keratin 19 antibody, anti-Keratin type i 40kD antibody, anti-krt19 antibody,anti-mgc15366 antibody.
Gene ID 3880, 16669
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Suggested working dilutions: immunofluorescence 1:50 - 1:100,Immunohistochemistry-Paraffin 1:500. Positive Controls: Skin
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/ml
Buffer 10mM PBS [pH 7.4], BSA. Preservative: 0.05% Sodium azide.
Preservative Sodium azide
Storage 4 °C
Takeda, Kojima, Ikejima et al.: "Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10895-900, 2008 (PubMed).

Alternatives for antigen "Keratin 19 (KRT19)", type "Antibodies"
Hosts (193), (118), (4), (1)
Reactivities (291), (56), (51), (21), (18), (16), (14), (7), (4), (3), (3), (3), (3), (1)
Applications (227), (165), (117), (81), (74), (66), (46), (40), (27), (17), (10), (10), (4), (3), (2), (2), (1), (1)
Conjugates (16), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (36), (6), (6), (6), (5), (5), (4), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1)
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