Did you know that you can buy products from over 140 different suppliers from us?

Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (N-Term), (Extracellular Domain) antibody

Details for Product No. ABIN152139
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, CXCR4, cb403, zgc:109863, CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr ... show more
FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, CXCR4, cb403, zgc:109863, CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4 show less
Epitope
N-Term, Extracellular Domain
(54), (17), (12), (10), (8), (7), (6), (6), (6), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(218), (111), (65), (30), (14), (12), (4), (2), (2), (1), (1), (1)
Host
Goat
(179), (41), (21), (12), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(162), (79), (77), (63), (38), (29), (27), (25), (24), (9), (8), (5), (4), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Catalog No. ABIN152139
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide (TEEMGSGDYDSMKEPCFREENANFNKC) corresponding to N-terminal extracellular domain of human CXCR4 receptor.
Specificity Peptide sequence is < 50% identical to other human chemokine receptors in this region
Purification Peptide affinity purified
Alternative Name CD184 / CXCR4
Background CXCR4 is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry ofhuman white blood cells. CXCR4 is also required for the infection by dual-tropic strainsof HIV1 and mediates CD4 independent infection by HIV2. The a chemokine SDF1 isthe ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 associates withthe surface CD4-gp120 complex before HIV enters target cells. CXCR4 messengerRNA levels correlated with HIV1 permissiveness in diverse human cell types. Antibodiesto CXCR4 block HIV1 and HIV2 fusion and infection of human target cells. The aminoterminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.CXCR4 is highly expressed in brain and heart, and in white blood cells, vascularendothelial cells, and umbilical cord endothelial cells. Alternate Names: anti-CD184 antibody, anti-Chemokine CXC Motif Receptor 4 antibody, anti-FB22antibody, anti-Fusin antibody, anti-HM89 antibody, anti-HSY3RR antibody, anti-LAP3antibody, anti-LCR1 antibody, anti-LESTR antibody, anti-NPY3R antibody, anti-NPYRantibody, anti-NPYRL antibody, anti-NPYY3 antibody, anti-NPYY3R antibody,anti-Probable G protein coupled receptor lcr1 homolog antibody, anti-WHIM antibody.
Gene Symbol: CXCR4
Gene ID 7852
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Application Notes Recommended dilutions: ELISA 1:25000, Immunohistochemistry 1:150, Immunohistochemistry-Paraffin 1:150, Western Blot 1:250
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 10 mM KHPO4, 140 mM NaCl, 1 mg/ml BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (N-Term), (Extracellular Domain) antibody Immunohistochemistry on paraffin sections of human spleen
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (N-Term), (Extracellular Domain) antibody (2) Anti-CXCR4 Inhibition of SDF-Induced Activation DU145
General Loetscher, Geiser, OReilly et al.: "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes." in: The Journal of biological chemistry, Vol. 269, Issue 1, pp. 232-7, 1994 (PubMed).

Bleul, Farzan, Choe et al.: "The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry." in: Nature, Vol. 382, Issue 6594, pp. 829-33, 1997 (PubMed).

Schimanski, Schwald, Simiantonaki et al.: "Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 5, pp. 1743-50, 2005 (PubMed).

Diomedi-Camassei, McDowell, De Ioris et al.: "Clinical significance of CXC chemokine receptor-4 and c-Met in childhood rhabdomyosarcoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 13, pp. 4119-27, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN152139
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
Did you look for something else?
back to top