CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term)

Details for Product anti-CXCR4 Antibody No. ABIN152139, Supplier: Log in to see
Antigen
  • CXC-R4
  • CXCR-4
  • cd184
  • d2s201e
  • fb22
  • hm89
  • hsy3rr
  • lap3
  • lcr1
  • lestr
  • npy3r
  • npyr
  • npyrl
  • npyy3r
  • whim
  • xcxcr4
  • cxcr4
  • CD184
  • Cmkar4
  • LESTR
  • PB-CKR
  • PBSF/SDF-1
  • Sdf1r
  • D2S201E
  • FB22
  • HM89
  • HSY3RR
  • LAP3
  • LCR1
  • NPY3R
  • NPYR
  • NPYRL
  • NPYY3R
  • WHIM
  • CXC-R4-B
  • CXCR-4-B
  • CXCR4
  • cb403
  • zgc:109863
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4b
  • neuropeptide Y receptor type 3
  • cxcr4
  • CXCR4
  • Cxcr4
  • cxcr4-b
  • cxcr4b
Alternatives
anti-Rat (Rattus) CXCR4 antibody for Confocal Microscopy
Epitope
N-Term
76
29
20
16
15
14
10
10
9
8
8
8
6
5
5
5
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
409
204
96
25
16
10
9
9
8
7
5
5
4
4
3
3
2
2
1
1
1
Host
Goat
239
177
67
26
2
Clonality
Polyclonal
Conjugate
This CXCR4 antibody is un-conjugated
23
17
16
15
14
12
11
11
11
11
9
8
7
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
256
227
114
98
95
61
41
36
32
19
14
8
6
6
4
3
3
2
2
2
2
2
1
Options
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Immunogen Synthetic peptide (TEEMGSGDYDSMKEPCFREENANFNKC) corresponding to N-terminal extracellular domain of human CXCR4 receptor.
Specificity Peptide sequence is < 50 % identical to other human chemokine receptors in this region
Purification Immunogen affinity purified
Alternative Name CXCR4 (CXCR4 Antibody Abstract)
Background Gene Symbol: CXCR4
Gene ID 7852
UniProt P61073
Research Area Adaptive Immunity, Receptors, Hematopoietic Progenitors, Innate Immunity, Chemokines, Cancer
Pathways Regulation of Cell Size, CXCR4-mediated Signaling Events
Application Notes Western Blot 1:250, ELISA 1:25000, Immunohistochemistry 1:150, Immunohistochemistry-Paraffin 1:150
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 10 mM KHPO4, 0.14M NaCl and 1.0 mg/mL BSA
Buffer contains: 0.1 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term) (ABIN152139) Immunohistochemistry on paraffin sections of human spleen
Immunofluorescence (IF) image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term) (ABIN152139) Anti-CXCR4 Inhibition of SDF-Induced Activation DU145
Product cited in: Hu, Zhang, Xu, Zhang, Chen, Cui, Yang, Shen: "Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain." in: Scientific reports, Vol. 7, Issue 1, pp. 4005, 2017 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).

Diomedi-Camassei, McDowell, De Ioris, Uccini, Altavista, Raschellà, Vitali, Mannarino, De Sio, Cozzi, Donfrancesco, Inserra, Callea, Dominici: "Clinical significance of CXC chemokine receptor-4 and c-Met in childhood rhabdomyosarcoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 13, pp. 4119-27, 2008 (PubMed).

Schimanski, Schwald, Simiantonaki, Jayasinghe, Goenner, Wilsberg, Junginger, Berger, Galle, Moehler: "Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 5, pp. 1743-50, 2005 (PubMed).

Background publications Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: "The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry." in: Nature, Vol. 382, Issue 6594, pp. 829-33, 1997 (PubMed).

Loetscher, Geiser, OReilly, Zwahlen, Baggiolini, Moser: "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes." in: The Journal of biological chemistry, Vol. 269, Issue 1, pp. 232-7, 1994 (PubMed).