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Details for Product No. ABIN152187

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody

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Synonyms HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hif1a, HIF1-alpha, HIF-1a, HIF1a, hif-1a
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 12 references available
Catalog no. ABIN152187
Quantity 5 vials
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Immunogen NB100-105, NB100-134 = Fusion protein containing amino acids 432-528 of humanHIF-1 alpha.
NB100-296 = Fusion protein containing amino acids 329-530 of human HIF-1alpha.
NB100-449 = A synthetic peptide mapping to a region between residues 775 and theC-terminus (residue 826) of human hypoxia-inducible factor 1, alpha subunit using thenumbering given in Swiss-Prot entry Q16665 (GeneID 3091).
ABIN151926 = A fusion protein including residues 530-825 of the mouse HIF-1 alphaprotein.
Clone 4 clones
Isotype IgG
Specificity These antibodies are specific for HIF-1 alpha. Species Reactivity: NB 100-105 recognizes human, sheep, mouse, rat, rabbit, ferret and bovine.NB 100-479 recognizes human, mouse, monkey and rat.NB 100-134 recognizes human and rat.NB 100-296 recognizes human.ABIN151900 recognizes human and mouse.
Alternative Name HIF1A / HIF1 alpha sampler
Background Hypoxia contributes significantly to the pathophysiology of major categories of humandisease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension,congenital heart disease and chronic obstructive pulmonary disease.HIF-1 is a nuclear protein that activates gene transcription in response to reducedcellular 02 concentration. HIF-1 activates the transcription of EPO, VEGF, iNOS, hemeoxygenase 1 and several other critical intracellular responses to hypoxia. HIF-1 is aheterodimer composed of HIF-1a and HIF-1b subunits. Both subunits are induced byhypoxia and rapidly decay upon return to normoxia and are basic-helix-loop-helix-PASproteins. Recent research indicates the ability to regulate hypoxia-inducible factors maybe related to tumor-related angiogenesis in certain cancers.
Gene ID 3091
Application Notes By Western blot, these antibodies recognize a band ~120 kDa, representing HIF-1 alphain induced tissues and cells. Multiple bands may be seen at 120 kDa representingpost-translational modification of HIF-1 alpha. Suggested working dilutions: *Western Blot - 1:500 -1:1,000 ****Nuclear extracts should be used for Western analysis.
Restrictions For Research Use only
Format Liquid
Buffer 0.025 ml samples of each antibody
Storage 4 °C
Haase, Glickman, Socolovsky et al.: "Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1583-8, 2001 (PubMed).

Joegi, uora, Nilsson et al.: "Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 10, pp. 7021-6, 2002 (PubMed).

Kong, Eltzschig, Karhausen et al.: "Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10440-5, 2004 (PubMed).

Covello, Simon, Keith: "Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth." in: Cancer research, Vol. 65, Issue 6, pp. 2277-86, 2005 (PubMed).

Forcheron, Legedz, Chinetti et al.: "Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 8, pp. 1711-7, 2005 (PubMed).

Karlsson, Edsjoe, Puahlman et al.: "Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia." in: Molecular cancer therapeutics, Vol. 4, Issue 7, pp. 1128-35, 2005 (PubMed).

Boisvert, Rose, Boullier et al.: "Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 3, pp. 563-9, 2006 (PubMed).

Galabova-Kovacs, Matzen, Piazzolla et al.: "Essential role of B-Raf in ERK activation during extraembryonic development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 5, pp. 1325-30, 2006 (PubMed).

Chade, Zhu, Mushin et al.: "Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 10, pp. 1706-8, 2006 (PubMed).

Villanueva, Cespedes, Gonzalez et al.: "bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 291, Issue 6, pp. R1677-87, 2006 (PubMed).

Grimmer, Balbus, Lang et al.: "Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels." in: The American journal of pathology, Vol. 169, Issue 2, pp. 491-502, 2006 (PubMed).

Wang, Kiss, Franklin et al.: "Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways." in: Journal of lipid research, Vol. 48, Issue 3, pp. 633-45, 2007 (PubMed).

Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)", type "Antibodies"
Hosts (179), (135), (1)
Reactivities (276), (120), (98), (78), (53), (50), (31), (28), (20), (19), (17), (4), (2), (2), (1), (1), (1), (1), (1)
Applications (256), (96), (74), (72), (57), (56), (52), (31), (19), (14), (11), (10), (9), (7), (2), (2), (1), (1)
Conjugates (33), (20), (19), (12), (12), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (36), (24), (16), (11), (8), (7), (6), (6), (6), (6), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)