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Details for Product No. ABIN152190

Egl Nine Homolog 1 (C. Elegans) (EGLN1) antibody

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Antigen
Synonyms C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6, AI503754, Hif-p4h-2, ORF13, Phd2, SM-20, zgc:92314, PHD-2, egln2, phd2, EGLN1
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 9 references available
Catalog no. ABIN152190
Quantity 7 vials
Price
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Immunogen The exact amino acid range is proprietary.
General Immunogen area:
NB 100-137 (LocusLink - 54583 Region - Internal)
NB 100-138 (LocusLink - 54583 Region - c-terminus)
NB 100-139 (LocusLink - 112399 Region - Internal)
NB 100-295 (LocusLink - 54681 Region - c-terminus)
NB 100-303 (LocusLink - 112399 Region - c-terminus)
NB 100-310 (LocusLink - 111298 Region - c-terminus)
ABIN250635 (mouse amino acid range 300-400).
Specificity NB 100-137 - PHD2/EGLN1NB 100-138 - PHD2/EGLN1NB 100-139 - PHD3/EGLN3NB 100-295 - PHD4NB 100-303 - PHD3/EGLN3ABIN151776 - PHD1/EGLN2NB 100-2219 - PHD2/EGLN1. Species Reactivity: All: Homo sapiens. NB 100-137 does not react with mouse.NB 100-138 does not react with mouse and mixed results in rat.NB 100-139 does not react with mouse but reacts with rat.NB 100-295 does not react with mouse and is unknown in rat.NB 100-303 reacts with mouse.ABIN151776 reacts with mouse and rat.Other species have not been tested.
Purification Affinity Purified
Alternative Name EGLN1 / PHD2 (Sample Pack)
Gene ID 54583
Application Notes These antibodies can be used for Western Blot at a dilution range of 1:500~1:1,000. Other applications, such as immunofluorescence, are not confirmed.
Restrictions For Research Use only
Format Liquid
Buffer 0.025 ml antibody per vial.
Storage 4 °C
Lu, Dalgard, Mohyeldin et al.: "Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1." in: The Journal of biological chemistry, Vol. 280, Issue 51, pp. 41928-39, 2005 (PubMed).

Stiehl, Wirthner, Koeditz et al.: "Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system." in: The Journal of biological chemistry, Vol. 281, Issue 33, pp. 23482-91, 2006 (PubMed).

McMahon, Charbonneau, Grandmont et al.: "Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24171-81, 2006 (PubMed).

Kondo, Seo, Yoshizaki et al.: "EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells." in: Cancer research, Vol. 66, Issue 20, pp. 9870-7, 2006 (PubMed).

Choi, Kim, Kim et al.: "AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 16, pp. 4472-81, 2007 (PubMed).

Baek, Liu, McDonald et al.: "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha." in: The Journal of biological chemistry, Vol. 282, Issue 32, pp. 23572-80, 2007 (PubMed).

Colla, Tagliaferri, Morandi et al.: "The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesi" in: Blood, Vol. 110, Issue 13, pp. 4464-75, 2007 (PubMed).

Bex, Knauth, Dambacher et al.: "A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein." in: Nucleic acids research, Vol. 35, Issue 21, pp. e142, 2007 (PubMed).

Chang, Loh, Ceradini et al.: "Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia." in: Circulation, Vol. 116, Issue 24, pp. 2818-29, 2007 (PubMed).

Alternatives for antigen "Egl Nine Homolog 1 (C. Elegans) (EGLN1)", type "Antibodies"
Hosts (56), (22)
Reactivities (70), (30), (12), (12), (5), (1), (1), (1)
Applications (65), (15), (14), (14), (13), (10), (9), (6), (4), (2)
Conjugates (7), (5), (5), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (10), (6), (5), (5), (3), (2), (2), (1), (1), (1), (1)
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