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Details for Product No. ABIN152191

Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

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Synonyms 53BP1, p202, Trp53bp1, Tp53bp1, m53BP1, TP53BP1, MGC160112
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN152191
Quantity 0.1 mL
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Immunogen A synthetic peptide, which represented a portion of human tumor protein p53-bindingprotein 1 encoded in exon 11, 12 and 19 (LocusLink ID 7158). This antibody is a cocktailhybrid of NB 100-304 and ABIN151771.
Specificity ABIN152191 is specific for human 53BP1 protein. Species Reactivity: Reacts with human in Western Blot and immunocytochemistry. Reacts with mouse inimmunocytochemistry (Western Blot has not been done using this antibody on mouseprotein).
Cross-Reactivity Human, Mouse (Murine)
Purification Affinity Purified
Alternative Name TP53BP1 (Cocktail)
Background P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes tothe presumptive sites of damage, specifically, double-strand breaks. This also suggestsa role in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.
Gene ID 7158
UniProt Q12888
Application Notes Suggested working dilutions: Western Blot 1:1,000 - 1:10,000 (ECL),Immunocytochemistry 1:100 - 1:1,000. Positive Controls: U205 cell lysates
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate (pH 7-8) buffer. Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Yanagawa, Funasaka, Tsutsumi et al.: "Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14." in: Cancer research, Vol. 67, Issue 18, pp. 8682-9, 2007 (PubMed).

Murga, Jaco, Fan et al.: "Global chromatin compaction limits the strength of the DNA damage response." in: The Journal of cell biology, Vol. 178, Issue 7, pp. 1101-8, 2007 (PubMed).

Toledo, Murga, Gutierrez-Martinez et al.: "ATR signaling can drive cells into senescence in the absence of DNA breaks." in: Genes & development, Vol. 22, Issue 3, pp. 297-302, 2008 (PubMed).

Pennarun, Granotier, Hoffschir et al.: "Role of ATM in the telomere response to the G-quadruplex ligand 360A." in: Nucleic acids research, Vol. 36, Issue 5, pp. 1741-54, 2008 (PubMed).

Alternatives for antigen "Tumor Protein P53 Binding Protein 1 (TP53BP1)", type "Antibodies"
Hosts (115), (10), (1)
Reactivities (123), (78), (42), (36), (12), (12)
Applications (86), (42), (32), (30), (29), (22), (20), (16), (4), (2)
Conjugates (8), (8), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (17), (13), (12), (10), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1)