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Details for Product No. ABIN152195

SCARB1 (3 Set) antibody

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Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
Host
Clonality Polyclonal
Application
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 14 references available
Catalog no. ABIN152195
Quantity 3 vials
Price
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Specificity Species Reactivity: See individual datasheets.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Background We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. TheScavenger Receptor, Class BI (SR-BI) binds HDLs and mediates selective uptake ofHDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liverand nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by adistinct mechanism.In mice, it seems that SR-BI plays a key role in determining the levels of plasmalipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Arai, Rinninger, Varban et al.: "Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 21, pp. 12050-5, 1999 (PubMed).

Willner, Tow, Buhman et al.: "Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1262-7, 2003 (PubMed).

Ma, Cilingiroglu, Otvos et al.: "Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2748-53, 2003 (PubMed).

Jordan, Shen, Olaso et al.: "Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 19, pp. 10866-71, 2003 (PubMed).

Liang, Kim, Vaziri: "HMG-CoA reductase inhibition reverses LCAT and LDL receptor deficiencies and improves HDL in rats with chronic renal failure." in: American journal of physiology. Renal physiology, Vol. 288, Issue 3, pp. F539-44, 2005 (PubMed).

Johansson, Rudling, Scanlan et al.: "Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 29, pp. 10297-302, 2005 (PubMed).

Martin, Atshaves, McIntosh et al.: "Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 290, Issue 1, pp. G36-48, 2005 (PubMed).

Dichek, Agrawal, El Andaloussi et al.: "Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology." in: American journal of physiology. Endocrinology and metabolism, Vol. 290, Issue 5, pp. E908-15, 2006 (PubMed).

Li, Guo, Asmis et al.: "Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death." in: Circulation research, Vol. 98, Issue 7, pp. e60-5, 2006 (PubMed).

Zhang, Yin, Liao et al.: "NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs." in: Journal of lipid research, Vol. 47, Issue 9, pp. 2055-63, 2006 (PubMed).

Joyce, Wagner, Basso et al.: "ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis." in: The Journal of biological chemistry, Vol. 281, Issue 44, pp. 33053-65, 2006 (PubMed).

Graham, Lemonidis, Whipple et al.: "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice." in: Journal of lipid research, Vol. 48, Issue 4, pp. 763-7, 2007 (PubMed).

Parathath, Darlington, de la Llera Moya et al.: "Effects of amino acid substitutions at glycine 420 on SR-BI cholesterol transport function." in: Journal of lipid research, Vol. 48, Issue 6, pp. 1386-95, 2007 (PubMed).

Nassir, Wilson, Han et al.: "CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine." in: The Journal of biological chemistry, Vol. 282, Issue 27, pp. 19493-501, 2007 (PubMed).

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