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Details for Product No. ABIN152196

APEX1 / REF-1 (2 Set) antibody

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Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
Host
Clonality Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152196
Quantity 2 vials
Price
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Specificity Species Reactivity: See individual datasheets.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Background We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for therepair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitatingthe DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and othertranscription factors. APE/ref-1 has also been shown to control p53 activity throughredox alteration. APE is linked to apoptosis, associated with thioredoxin, and alteredlevels of APE/ref-1 have been found in some cancers. APE appears to form a uniquelink between the DNA base excision pathway, oxidative signaling, transcriptionregulation, cancer and cell-cycle control.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Evans, Limp-Foster, Kelley: "Going APE over ref-1." in: Mutation research, Vol. 461, Issue 2, pp. 83-108, 2001 (PubMed).

Zou, Luo, Reed et al.: "Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain." in: Blood, Vol. 109, Issue 5, pp. 1917-22, 2007 (PubMed).

Briegert, Kaina: "Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents." in: Cancer research, Vol. 67, Issue 1, pp. 26-31, 2007 (PubMed).

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