Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Add to Basket
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN152198

Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms API4, EPR-1, AP14, bir5a, survivin, LOC398389, BIRC5, BIR1, Su2, Survivin, Survivin1, XBIR1, api4, epr-1, svv1, xSurvivin1, xsurv, SIX, Su1, svv2, birc5, xSurvivin, xSurvivin2
Reactivity
»Alternatives Dog (Canine)
Host
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN152198
Quantity 3 vials
Price
Contact our Customer Service for availability and price in your country.
Shipping to
Clone Var-
Cross-Reactivity Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)
Purification Purified
Alternative Name IAP4 / BIRC5
Background We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability.Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a c-terminus RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression isturned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all of themost common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivinappears to be situated at the crossroads of cell death and cell division, governing acheckpoint involved in cytokinesis while also suppressing apoptosis.Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury.
Research Area Cancer, Apoptosis/Necrosis, Neurology
Restrictions For Research Use only
Ambrosini, Adida, Sirugo et al.: "Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 11177-82, 1998 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Li, Ackermann, Bennett et al.: "Pleiotropic cell-division defects and apoptosis induced by interference with survivin function." in: Nature cell biology, Vol. 1, Issue 8, pp. 461-6, 2000 (PubMed).

Grossman, McNiff, Li et al.: "Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma." in: The Journal of investigative dermatology, Vol. 113, Issue 6, pp. 1076-81, 2000 (PubMed).

Adida, Haioun, Gaulard et al.: "Prognostic significance of survivin expression in diffuse large B-cell lymphomas." in: Blood, Vol. 96, Issue 5, pp. 1921-5, 2000 (PubMed).

Fortugno, Beltrami, Plescia et al.: "Regulation of survivin function by Hsp90." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 13791-6, 2003 (PubMed).

Paduano, Villa, Pennati et al.: "Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells." in: Molecular cancer therapeutics, Vol. 5, Issue 1, pp. 179-86, 2006 (PubMed).

Xia, Altieri: "Mitosis-independent survivin gene expression in vivo and regulation by p53." in: Cancer research, Vol. 66, Issue 7, pp. 3392-5, 2006 (PubMed).

Alternatives for antigen "Baculoviral IAP Repeat-Containing 5 (BIRC5)", type "Antibodies"
Hosts (96), (33), (3)
Reactivities (110), (45), (24), (8), (4), (3), (3), (3), (2)
Applications (104), (49), (48), (31), (23), (16), (11), (10), (5), (2), (1), (1), (1), (1), (1), (1)
Conjugates (5), (5), (5)
Epitopes (29), (8), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon