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Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody
Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|8 references available|
|Price||Product not available in this region.|
|Alternative name||IAP4 / BIRC5|
|Cross-Reactivity||Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)|
|Description||We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability.Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a c-terminus RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression isturned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all of themost common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivinappears to be situated at the crossroads of cell death and cell division, governing acheckpoint involved in cytokinesis while also suppressing apoptosis.Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury.|
|Synonyms||API4, EPR-1, AP14, BIRC5, MGC133855, DKFZp468N162, Api4, TIAP, AAC-11, survivin40, bir5a, survivin, bir1-A, svv1, XBIR1, Xsvv1, birc5.1-A, xSurvivin, XSurvivin1, LOC398389, LOC398418, Su2, birc5.1-B, BIR1, Survivin, Survivin1, xSurvivin1, SIX, Su1, api4, svv2, birc5, epr-1, xSurvivin2|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Research Area||Cancer, Apoptosis/Necrosis, Neurology|
|Restrictions||For Research Use only|
|The top photo is a no primary antibody control stain and the bottom photo is anti-survivin staining of melanoma. Photo courtesy of Dr. Dario Altieri, Yale University.|
Ambrosini, Adida, Sirugo et al.: "Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 11177-82, 1998 (PubMed).
Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).
Li, Ackermann, Bennett et al.: "Pleiotropic cell-division defects and apoptosis induced by interference with survivin function." in: Nature cell biology, Vol. 1, Issue 8, pp. 461-6, 2000 (PubMed).
Grossman, McNiff, Li et al.: "Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma." in: The Journal of investigative dermatology, Vol. 113, Issue 6, pp. 1076-81, 2000 (PubMed).
Adida, Haioun, Gaulard et al.: "Prognostic significance of survivin expression in diffuse large B-cell lymphomas." in: Blood, Vol. 96, Issue 5, pp. 1921-5, 2000 (PubMed).
Fortugno, Beltrami, Plescia et al.: "Regulation of survivin function by Hsp90." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 13791-6, 2003 (PubMed).
Paduano, Villa, Pennati et al.: "Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells." in: Molecular cancer therapeutics, Vol. 5, Issue 1, pp. 179-86, 2006 (PubMed).
Xia, Altieri: "Mitosis-independent survivin gene expression in vivo and regulation by p53." in: Cancer research, Vol. 66, Issue 7, pp. 3392-5, 2006 (PubMed).
|Hosts||Rabbit (17), Mouse (5)|
|Reactivities||Human (19), Mouse (Murine) (9), Rat (Rattus) (8), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1), Rabbit (1)|
|Applications||Western Blotting (WB) (20), ELISA (12), Immunohistochemistry (IHC) (9), Immunofluorescence (IF) (5), Flow Cytometry (FACS) (2), Immunoprecipitation (IP) (2)|
|Epitopes||C-Term (6), N-Term (3), AA 1-99 (1), Center (1), Transcript Variant 1 (1)|