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Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody

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Synonyms API4, EPR-1, AAC-11, Api4, TIAP, survivin40, AP14
Dog (Canine)
(72), (37), (10), (1), (1), (1)
(63), (25), (3)
Clonality (Clone)
Polyclonal ()
(2), (2), (2)
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(68), (28), (20), (18), (14), (7), (6), (6), (3), (2), (1), (1), (1)
Pubmed 8 references available
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Quantity 3 vials
Shipping to United States ( )
Clone Var-
Cross-Reactivity Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)
Purification Purified
Alternative Name IAP4 / BIRC5 (BIRC5 Antibody Abstract)
Background We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability.Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a c-terminus RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression isturned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all of themost common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivinappears to be situated at the crossroads of cell death and cell division, governing acheckpoint involved in cytokinesis while also suppressing apoptosis.Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury.
Research Area Cancer, Apoptosis/Necrosis, Neurology
Pathways Apoptosis, Cell Division Cycle
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Supplier Images
Immunohistochemistry (IHC) image for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody (ABIN152198) The top photo is a no primary antibody control stain and the bottom photo is anti-sur...
Product cited in: Xia, Altieri: "Mitosis-independent survivin gene expression in vivo and regulation by p53." in: Cancer research, Vol. 66, Issue 7, pp. 3392-5, 2006 (PubMed).

Paduano, Villa, Pennati et al.: "Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells." in: Molecular cancer therapeutics, Vol. 5, Issue 1, pp. 179-86, 2006 (PubMed).

Fortugno, Beltrami, Plescia et al.: "Regulation of survivin function by Hsp90." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 13791-6, 2003 (PubMed).

Adida, Haioun, Gaulard et al.: "Prognostic significance of survivin expression in diffuse large B-cell lymphomas." in: Blood, Vol. 96, Issue 5, pp. 1921-5, 2000 (PubMed).

Grossman, McNiff, Li et al.: "Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma." in: The Journal of investigative dermatology, Vol. 113, Issue 6, pp. 1076-81, 2000 (PubMed).

Li, Ackermann, Bennett et al.: "Pleiotropic cell-division defects and apoptosis induced by interference with survivin function." in: Nature cell biology, Vol. 1, Issue 8, pp. 461-6, 2000 (PubMed).

Background publications Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Ambrosini, Adida, Sirugo et al.: "Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 11177-82, 1998 (PubMed).

Catalog No. ABIN152198
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