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Breast Cancer 1 (BRCA1) antibody

Details for Product No. ABIN152223
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Antigen
Synonyms BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Reactivity
Human
(367), (45), (25), (13), (1), (1), (1), (1)
Host
Mouse
(325), (60), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(17), (15), (12), (9), (9), (9), (9), (9), (9), (9), (9), (3), (3), (3), (1), (1), (1)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(222), (96), (90), (89), (74), (69), (56), (13), (9), (3), (2), (1)
Pubmed 1 reference available
Quantity 3 vials
Shipping to United States (Change)
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Catalog No. ABIN152223
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Clone Var-
Isotype IgG
Cross-Reactivity Human
Purification Purified
Alternative Name BRCA1 / RNF53
Background We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.BRCA1 (breast and ovarian cancer susceptibility protein 1) is a RING finger proteincontaining a BRCT domain. BRCA1 exists as a heterodimer with 22 possible isoforms.The full length protein has a reported molecular weight of 208 kD. BRCA1 localizes tothe mitotic spindle microtubules, centriole walls, pericentriolar fibers at centrosomes.Unphosphorylated BRCA1 localizes on chromosomes from metaphase throughtelophase, phosphorylated BRCA1 resides in inner chromosomal structure, centrosome,cleavage furrow during prophase through telophase, and relocalizes to the perinuclearregion when cells are subjected to IR or UV radiation in S phase. BRCA1 acts as atumor suppressor and can function as a secreted growth inhibitory protein, participate intranscription coupled repair of oxidative DNA damage, X-chromosome inactivation, andcan function as a E3 ubiquitin ligase. BRCA1 can be transcriptionally downregulated byEts-2, Brg-1, and Hmga-1. BRCA1 can be modified by glycosylation, ubiquitination andphosphorylation by CDK4, ATM/ATR, cdk2, and hChk2. The BRCA1 protein has beenreported to interact with RNA polymerase II holoenzyme and BARD1. BRCA1 containsat least two nuclear localization signals and is proposed to be a tumor suppressorprotein. It is a serine phosphoprotein that undergoes hyperphosphorylation during lateG1 and S phases of the cell cycle and is transiently dephosphorylated early after Mphase. BRCA1 protein alters in a qualitative and quantitative manner during cell cycleprogression. The amount of BRCA1 protein is highest during S phase and remainselevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA1function confers an increased susceptibility for both breast and ovarian cancer.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Supplier Images
anti-Breast Cancer 1 (BRCA1) antibody anti-Breast Cancer 1 (BRCA1) antibody
anti-Breast Cancer 1 (BRCA1) antibody (2) Detection of BRCA1 in U2OS whole cell lysate using ABIN152031. 1 minute ECL detection
anti-Breast Cancer 1 (BRCA1) antibody (3) Detection of BRCA1 in MCF-7 whole cell lysate using ABIN152032. 12 minute ECL exposure
General Okada, Ouchi: "Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 2015-20, 2003 (PubMed).

Validation Images
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