V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) (AA 408-420) antibody

Details for Product No. ABIN152253
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Antigen
Synonyms LOC100136746, RNCMYC, c-myc, mMyc, AU016757, Myc2, Niard, Nird, bHLHe39, MYC, cmyc, zc-myc, MRTL, MYCC, c-Myc, C-MYC, CMYC, CMyc
Epitope
AA 408-420
(58), (52), (49), (36), (23), (17), (15), (14), (14), (12), (12), (7), (5), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Human, Mouse (Murine), Yeast
(519), (186), (158), (44), (15), (13), (12), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(370), (179), (25), (14), (4), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(34), (32), (24), (8), (7), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(427), (179), (171), (113), (112), (111), (54), (52), (40), (31), (27), (20), (15), (10), (8), (6), (3), (1)
Pubmed 5 references available
Quantity 0.1 mL
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Catalog No. ABIN152253
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Immunogen A synthetic peptide corresponding to amino acids 408-420 (AEEQKLISEEDL) of human c-Myc, conjugated to KLH.
Clone 9E11
Isotype IgG2a kappa
Purification Protein A purified
Alternative Name C-Myc
Background The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene onhuman chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells andplays an important role in cellular proliferation, differentiation, apoptosis and cell cycleprogression. The phosphorylation of c-Myc has been investigated and previous studieshave suggested a functional association between phosphorylation at Thr58/Ser62 byglycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminalKinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown thatc-Myc is essential for tumor cell development in vasculogenesis and angiogenesis thatdistribute blood throughout the cells, and which brought extensive attention in thedevelopment of new therapeutic approach for cancer treatment. Alternate Names: anti-c Myc antibody, anti-Cellular myelocytomatosis oncogene antibody, anti-Mycprotein antibody, anti-Myc proto oncogene protein antibody, anti-Myc2 antibody,anti-Niard antibody, anti-Nird antibody, anti-Transcription factor p64 antibody, anti-v mycavian myelocytomatosis viral oncogene homolog antibody, anti-v myc myelocytomatosisviral oncogene homolog (avian) antibody.
Gene Symbol: MYC
Gene ID 4609, 17869
UniProt P01106
Application Notes This c-Myc antibody (clone 9E11) is useful for Flow Cytometry, ChIP, Immunoprecipitation, ELISA, Immunohistochemistry- Frozen and Paraffin and Western blot.
Recommended dilutions: Chromatin Immunoprecipitation 2 µg / 500 µg extract, ELISA 1:100-1:2000, Flow Cytometry 1:200-1:400, Immunohistochemistry 1:100, Immunohistochemistry-Frozen 1:100, Immunohistochemistry-Paraffin 1:100, Immunoprecipitation 2µg/mg lysate, Western Blot 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1.1 mg/mL
Buffer PBS
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Locker, Dowle, Ellis et al.: "c-myc oncogene product expression and prognosis in operable breast cancer." in: British journal of cancer, Vol. 60, Issue 5, pp. 669-72, 1989 (PubMed).

Evan, Lewis, Ramsay et al.: "Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product." in: Molecular and cellular biology, Vol. 5, Issue 12, pp. 3610-6, 1986 (PubMed).

Zhang, Richardson, Roberts et al.: "The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9424-36, 2004 (PubMed).

Robert, Pokholok, Hannett et al.: "Global position and recruitment of HATs and HDACs in the yeast genome." in: Molecular cell, Vol. 16, Issue 2, pp. 199-209, 2004 (PubMed).

Sanders, Gruppuso: "Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation." in: Biochimica et biophysica acta, Vol. 1743, Issue 1-2, pp. 141-50, 2005 (PubMed).

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