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Details for Product No. ABIN152253

V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) antibody

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Antigen
Synonyms MRTL, MYCC, bHLHe39, c-Myc, CMYC, c-myc, RNCMYC, mMyc, C-MYC, MYC, cmyc, zc-myc, AU016757, Myc2, Niard, Nird, LOC100136746
Reactivity
»Alternatives Chicken, Human, Mouse (Murine), Yeast
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Chromatin Immunoprecipitation (ChIP), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN152253
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide: AEEQKLISEEDL conjugated to KLH, corresponding to amino acids408-420 of Human c-Myc.
Clone 9E11
Isotype IgG2a
Specificity Species Reactivity: Cross-reacts with Human, Mouse and Chicken. Not yet tested in other species. Localization: Nuclear.
Cross-Reactivity Chicken, Human, Mouse (Murine)
Purification Purified
Alternative Name C-Myc
Background The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene onhuman chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells andplays an important role in cellular proliferation, differentiation, apoptosis and cell cycleprogression. The phosphorylation of c-Myc has been investigated and previous studieshave suggested a functional association between phosphorylation at Thr58/Ser62 byglycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminalKinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown thatc-Myc is essential for tumor cell development in vasculogenesis and angiogenesis thatdistribute blood throughout the cells, and which brought extensive attention in thedevelopment of new therapeutic approach for cancer treatment. Alternate Names: anti-c Myc antibody, anti-Cellular myelocytomatosis oncogene antibody, anti-Mycprotein antibody, anti-Myc proto oncogene protein antibody, anti-Myc2 antibody,anti-Niard antibody, anti-Nird antibody, anti-Transcription factor p64 antibody, anti-v mycavian myelocytomatosis viral oncogene homolog antibody, anti-v myc myelocytomatosisviral oncogene homolog (avian) antibody.
Gene ID 4609, 17869
Application Notes Suggested working dilutions: chromatin immunoprecipitation 2ul per 0.5 mg of extract,Western Blot 1:500-1:1,000. Positive Controls: HL-60 cells or breast tumors.
Restrictions For Research Use only
Format Liquid
Concentration 1.1 mg/ml
Buffer Phosphate buffered saline. Preservative: No Preservative.
Storage 4 °C
Locker, Dowle, Ellis et al.: "c-myc oncogene product expression and prognosis in operable breast cancer." in: British journal of cancer, Vol. 60, Issue 5, pp. 669-72, 1989 (PubMed).

Evan, Lewis, Ramsay et al.: "Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product." in: Molecular and cellular biology, Vol. 5, Issue 12, pp. 3610-6, 1986 (PubMed).

Zhang, Richardson, Roberts et al.: "The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9424-36, 2004 (PubMed).

Robert, Pokholok, Hannett et al.: "Global position and recruitment of HATs and HDACs in the yeast genome." in: Molecular cell, Vol. 16, Issue 2, pp. 199-209, 2004 (PubMed).

Sanders, Gruppuso: "Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation." in: Biochimica et biophysica acta, Vol. 1743, Issue 1-2, pp. 141-50, 2005 (PubMed).

Alternatives for antigen "V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC)", type "Antibodies"
Hosts (295), (155), (19), (17), (4), (4)
Reactivities (436), (195), (168), (28), (26), (25), (24), (20), (14), (7), (6), (5), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (345), (154), (126), (123), (116), (85), (50), (50), (41), (20), (10), (8), (7), (6), (6), (1), (1)
Conjugates (29), (24), (18), (7), (5), (5), (5), (5), (5), (5), (5), (5), (2), (1), (1), (1), (1), (1)
Epitopes (43), (41), (33), (32), (25), (18), (11), (10), (9), (6), (5), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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