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Details for Product No. ABIN152302

Profilin 1 (PFN1) antibody

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Synonyms ALS18, Pfn, PRO1, F6F22.21, F6F22_21, PFN1, PROFILIN 1, profilin 1, GmPRO1, GmPRO2, Profilin-1, profilin-1, profilin, MGC130883, Profilin1, XProfilin1, sb:cb813, wu:fa91a03
»Alternatives Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152302
Quantity 0.1 mL
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Immunogen Porcine and human platelet profilin affinity purified on the antigen.
Specificity ABIN152302 is specific for profilin I protein but also reacts with profilin II. Species Reactivity: ABIN152302 can be used to detect human, porcine, rat,chicken, marsu pial, and mouseprofilin protein.
Cross-Reactivity Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
Purification Affinity Purified
Alternative Name Profilin-1 / PFN1
Background Profilin is an ubiquitous small (12-15 kDa) phosphoinositides and poly-L-proline bindingprotein that plays a role both in signal transduction pathways and actin filamentdynamics. There are two mammalian profilins with similar biochemical properties butdifferent expression patterns. Whereasprofilin I appears to be highly expressed in most tissues except for skeletal muscle,profilin II ispredominantly expressed in brain and at lower levels also in skeletal muscle, uterus andkidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamicmembrane areas like the leading edge and ruffling membranes. Alternate Names: anti-Pfn antibody, anti-PFN1 antibody.
Gene ID 5216, 18643, 64303
Application Notes Suggested working dilutions: Western Blot 0.1-0.2 ug/ml. Positive Controls: Human platelet protein (25ug)
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/ml
Buffer Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage -20 °C
Salazar, Bell, Davis: "Coordinate induction of the actin cytoskeletal regulatory proteins gelsolin, vasodilator-stimulated phosphoprotein, and profilin during capillary morphogenesis in vitro." in: Experimental cell research, Vol. 249, Issue 1, pp. 22-32, 1999 (PubMed).

Hauser, Knobeloch, Eigenthaler et al.: "Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 8120-5, 1999 (PubMed).

Giesemann, Rathke-Hartlieb, Rothkegel et al.: "A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems." in: The Journal of biological chemistry, Vol. 274, Issue 53, pp. 37908-14, 2000 (PubMed).

Alternatives for antigen "Profilin 1 (PFN1)", type "Antibodies"
Hosts (39), (7)
Reactivities (40), (24), (22), (22), (14), (3), (2), (2), (2), (1), (1), (1)
Applications (35), (15), (12), (11), (10), (3), (2), (1), (1), (1), (1)
Conjugates (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (3), (2)