Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) antibody

Antigen: Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD)

Synonyms: PGDH, PGDH1, 15-PGDH, SDR36C1, MGC80546, MGC79454, MGC127443, HPGD, DKFZp469E0623, AV026552, MGC14001

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN152315

Additional Information

Alternative name: HPGD

Gene ID: 3248

Immunogen: Purified type I human placental 15-PGDH protein.

Cross-Reactivity: Human

Description: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a novel tumor suppressor in theCOX-2 pathway. The protein is found in many normal tissues and appears to bedown-regulated in colorectal and lung carcinoma tissue. Alternate Names: anti-Prostaglandin dehydrogenase 1 antibody, anti-PGDH antibody, anti-HPGDantibody, anti-PGDH1 antibody, anti-15 PGDH antibody, anti-15-hydroxy prostaglandindehydrogenase antibody, anti-15-hydroxyprostaglandin dehydrogenase [NAD+]antibody.

Specificity: This antibody is specific for 15-PGDH. Species Reactivity: This antibody reacts with human 15-PGDH protein. No other species have been tested. Localization: Cytoplasmic.

Application Details

Application Notes: Positive Controls: Treated A549 lung carcinoma cell lysates (see note) and LoVo colon carcinoma celllysates.

Concentration: 2.0 mg/ml

Purification: Purified

Buffer: Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.

Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Restrictions: For Research Use only

Images

anti-Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) antibody

Publications

Giannoulias, Patel, Holloway et al.: "Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 3, pp. 1345-52, 2002 (PubMed).

Ding, Tong, Liu et al.: "NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer." in: Carcinogenesis, Vol. 26, Issue 1, pp. 65-72, 2004 (PubMed).

Backlund, Mann, Holla et al.: "Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer." in: Cancer research, Vol. 68, Issue 22, pp. 9331-7, 2008 (PubMed).

Hughes, Otani, Yang et al.: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 4, pp. 241-9, 2009 (PubMed).