NAD(P)H Dehydrogenase, Quinone 1 (NQO1) antibody

Details for Product No. ABIN152344
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Antigen
Synonyms DIA4, NADPH-d, DTD, QR1, DHQU, NMOR1, NMORI, Dtd, Ox1, Qr1, Dia4, Nmo1, Ox-1, Nmo-1, Nmor1, AV001255, zgc:77191, wu:fb63c10, nqo1
Reactivity
Dog (Canine), Human, Monkey, Rat (Rattus)
(102), (28), (28), (15), (12), (9), (4), (1)
Host
Mouse
(55), (39), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(93), (36), (32), (25), (23), (15), (14), (10), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN152344
Quantity 0.1 mL
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Immunogen Full length recombinant NQO1 (from human lung).
Clone AI80
Isotype IgG1
Specificity This antibody is specific for NQO1. It does not cross-react with NQO2. Species Reactivity: Cross-reacts with human and rat. Cross-reacts with monkey and dog inimmunohistochemistry. Cross-reactivity with mouse is extremely poor. Not yet tested inother species. Localization: Cytoplasmic (primarily), nuclear (faintly).
Cross-Reactivity Dog (Canine), Human, Monkey
Purification Purified
Alternative Name NQO1
Background NQO1 is a 2-electron reductase that detoxifies quinones derived from the oxidation ofphenolic metabolites of benzene. Individuals homozygous for the T/T form of the609C-T polymorphism have an increased risk of benzene hematotoxicity. Alternate Names: anti-DHQU antibody, anti-DIA4 antibody, anti-Diaphorase (NADH/NADPH) (cytochromeb-5 reductase) antibody, anti-Diaphorase (NADH/NADPH) antibody, anti-Diaphorase 4antibody, anti-DTD antibody, anti-NAD(P)H dehydrogenase quinone 1 antibody,anti-NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1 antibody, anti-NMOR1antibody, anti-NMORI antibody, anti-QR1 antibody, anti-NQO-1 antibody, anti-NADPHquinone oxidoreductase-1 antibody.
Gene ID 1728, 18104, 24314
UniProt P15559
Research Area Signaling, Metabolism
Application Notes Suggested working dilutions: Western Blot 1:1,000-1:10,000 (ECL)
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/ml
Buffer Tris-glycine and 150mM NaCl. Preservative: Sodium Azide
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-NAD(P)H Dehydrogenase, Quinone 1 (NQO1) antibody Detection of NQO1 in A549 lysates using ABIN152344. Lane 1: 0.5 ug/ml. Lane 2: 2 ug/ml. Exposure: 1 second.
General Siegel, Franklin, Ross: "Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 4, Issue 9, pp. 2065-70, 1998 (PubMed).

Slitt, Cherrington, Dieter et al.: "trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors." in: Molecular pharmacology, Vol. 69, Issue 5, pp. 1554-63, 2006 (PubMed).

Lee, Bhora, Sun et al.: "Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 2, pp. L255-65, 2008 (PubMed).

Cho, Imani, Miller-DeGraff et al.: "Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 2, pp. 138-50, 2009 (PubMed).

Salama, Kamel, Diaz-Arrastia et al.: "Effect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 1, pp. 285-93, 2009 (PubMed).

Hosts (55), (39), (11)
Reactivities (102), (28), (28), (15), (12), (9), (4), (1)
Applications (93), (36), (32), (25), (23), (15), (14), (10), (4), (3), (2), (2), (1), (1)
Conjugates (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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