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Estrogen Receptor 2 (ER Beta) (ESR2) antibody

Details for Product No. ABIN152348, Supplier: Log in to see
Antigen
  • CERB
  • er
  • ER-BETA
  • er-beta
  • ER-beta
  • Erb
  • ERB
  • erb
  • erb1
  • Erb2
  • erb2
  • ERBETA
  • ERbeta
  • erbeta
  • ERBeta2
  • ER[b]
  • ER[b]1
  • esr-beta
  • ESR-BETA
  • esr2
  • Esr2
  • ESR2
  • esrb
  • ESRB
  • Estrb
  • estrb
  • ESTRB
  • nr3a2
  • NR3A2
  • zfER-beta1
  • zfER[b]1
Alternatives
anti-Human Estrogen Receptor 2 (ER Beta) antibody for Immunofluorescence
Reactivity
Human
399
135
111
33
32
30
26
22
5
3
1
1
1
1
Host
Mouse
267
133
17
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
21
19
17
16
9
9
7
7
7
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
Application
Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
307
151
98
83
77
53
50
37
37
29
8
4
4
4
3
3
Supplier
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Immunogen Amino acids 1-153 of human ER-Beta expressed in E. coli.
Clone 6A12
Isotype IgG2b kappa
Specificity This is specific for Estrogen receptor-Beta.
Purification Protein G purified
Alternative Name ER beta/nr3a2 (ESR2 Antibody Abstract)
Background Gene Symbol: ESR2
Gene ID 2100
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway
Application Notes Western Blot 1-5 μg/mL, Chromatin Immunoprecipitation, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS ( pH 7.4)
Buffer contains: No Preservative
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C,-80 °C
Storage Comment Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Product cited in: Vivar, Saunier, Leitman, Firestone, Bjeldanes: "Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane." in: Endocrinology, Vol. 151, Issue 4, pp. 1662-7, 2010 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Vivar, Zhao, Saunier, Griffin, Mayba, Tagliaferri, Cohen, Speed, Leitman: "Estrogen receptor beta binds to and regulates three distinct classes of target genes." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22059-66, 2010 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Ivanova, Mazhawidza, Dougherty, Minna, Klinge: "Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells." in: Molecular and cellular endocrinology, Vol. 305, Issue 1-2, pp. 12-21, 2009 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Klinge, Wickramasinghe, Ivanova, Dougherty: "Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 7, pp. 2185-97, 2008 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Cvoro, Paruthiyil, Jones, Tzagarakis-Foster, Clegg, Tatomer, Medina, Tagliaferri, Schaufele, Scanlan, Diamond, Cohen, Leitman: "Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract." in: Endocrinology, Vol. 148, Issue 2, pp. 538-47, 2007 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Cvoro, Tzagarakis-Foster, Tatomer, Paruthiyil, Fox, Leitman: "Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression." in: Molecular cell, Vol. 21, Issue 4, pp. 555-64, 2006 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Tee, Rogatsky, Tzagarakis-Foster, Cvoro, An, Christy, Yamamoto, Leitman: "Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta." in: Molecular biology of the cell, Vol. 15, Issue 3, pp. 1262-72, 2004 (PubMed). (Sample species: Human). Further details: Chromatin Immunoprecipitation

Hopp, Weiss, Parra, Cui, Osborne, Fuqua: "Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 22, pp. 7490-9, 2004 (PubMed).

Konstantinopoulos, Kominea, Vandoros, Sykiotis, Andricopoulos, Varakis, Sotiropoulou-Bonikou, Papavassiliou: "Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation." in: European journal of cancer (Oxford, England : 1990), Vol. 39, Issue 9, pp. 1251-8, 2003 (PubMed).

Bianco, Perry, Smith, Templeton, Montano: "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage." in: Molecular endocrinology (Baltimore, Md.), Vol. 17, Issue 7, pp. 1344-55, 2003 (PubMed).

Speirs: "Correspondence re: S. A. W. Fuqua et al., Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res.,63: 2434-2439, 2003." in: Cancer research, Vol. 63, Issue 24, pp. 9055, 2003 (PubMed).

Speirs, Skliris, Burdall, Carder: "Distinct expression patterns of ER alpha and ER beta in normal human mammary gland." in: Journal of clinical pathology, Vol. 55, Issue 5, pp. 371-4, 2002 (PubMed).

Saji, Omoto, Shimizu, Warner, Hayashi, Horiguchi, Watanabe, Hayashi, Gustafsson, Toi: "Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor." in: Cancer research, Vol. 62, Issue 17, pp. 4849-53, 2002 (PubMed).