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Details for Product No. ABIN152451

Tachykinin Receptor 1 (TACR1) antibody

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Synonyms SPR, NK1R, NKIR, TAC1R, Tac1r, Nk1r, Spr, nk1R, ASPR
»Alternatives Dog (Canine), Guinea Pig, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 16 references available
Catalog no. ABIN152451
Quantity 0.1 mL
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Immunogen ABIN152451 was raised against a syntheticpeptide at the c-terminus of rat NK-1 conjugated to bovine thyroglobulin.
Specificity ABIN152451 is specific to the NK-1 receptor. Staining of cells transfected with NK-1 wasabolished by preabsorption of the antisera with NK-1. Specificity was also verified bythe localization of immunohistochemical staining with ABIN152451 in neurons in thedorsal horn of the spinal cord and to neurons and muscle cells in the ileum which areknown to express high levels of NK-1. (7). Species Reactivity: ABIN152451 can be used for detection of NK-1 receptor in rat, mouse and guinea pigsamples. Localization: In immunohistochemical experiments, plasma membrane staining is observed.
Cross-Reactivity Guinea Pig, Mouse (Murine), Rat (Rattus)
Purification Serum
Background The tachykinins belong to an evolutionary conserved family of peptide neurotransmittersthat share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an establishedrole in neurotransmission. The mammalian tachykinins include substance P, neurokininA (NKA) and neurokinin B (NKB) which exert their effects by binding to specificreceptors. Tachykinin peptides are important in the mediation of many physiologicaland pathological processes including inflammation, pain, migraine headache and allergyinduced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 whichhave preferential affinities for SP, NKA and NKB respectively. All three receptors sharea high degree of sequence homology, have seven transmembrane spanning domainsand similar signal transduction mechanisms (e.g. G-protein coupled activation ofphospholipase C). Alternate Names: anti-NK1 receptor antibody, anti-NK1R antibody, anti-SPR antibody, anti-Substance Preceptor antibody, anti-TAC1R antibody, anti-Tachykinin receptor 1 antibody,anti-TACR1 antibody, anti-NK-1r antibody, anti-Neurokinin 1 Receptor antibody.
Gene ID 6869, 24807
UniProt P14600
Research Area Hormones, Receptors
Application Notes Suggested working dilutions: Immunohistochemistry-Frozen 1/1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Preservative: No preservative.
Storage -20 °C
Vigna, Bowden, McDonald et al.: "Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 14, Issue 2, pp. 834-45, 1994 (PubMed).

Mantyh, Allen, Ghilardi et al.: "Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2622-6, 1995 (PubMed).

Mantyh, DeMaster, Malhotra et al.: "Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation." in: Science (New York, N.Y.), Vol. 268, Issue 5217, pp. 1629-32, 1995 (PubMed).

Mantyh, Rogers, Ghilardi et al.: "Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo." in: Brain research, Vol. 719, Issue 1-2, pp. 8-13, 1997 (PubMed).

Mantyh, Pappas, Lapp et al.: "Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum." in: Gastroenterology, Vol. 111, Issue 5, pp. 1272-80, 1996 (PubMed).

Allen, Rogers, Ghilardi et al.: "Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 17, Issue 15, pp. 5921-7, 1997 (PubMed).

Mantyh, Rogers, Honore et al.: "Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor." in: Science (New York, N.Y.), Vol. 278, Issue 5336, pp. 275-9, 1997 (PubMed).

Anderson, Seybold: "Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception." in: Neuroscience letters, Vol. 283, Issue 1, pp. 29-32, 2000 (PubMed).

Tooney, Au, Chahl: "Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex." in: Neuroscience letters, Vol. 283, Issue 3, pp. 185-8, 2000 (PubMed).

Setou, Nakagawa, Seog et al.: "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport." in: Science (New York, N.Y.), Vol. 288, Issue 5472, pp. 1796-802, 2000 (PubMed).

Yip, Chahl: "Localization of NK1 and NK3 receptors in guinea-pig brain." in: Regulatory peptides, Vol. 98, Issue 1-2, pp. 55-62, 2001 (PubMed).

Ma, Huang, Chien et al.: "Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct." in: American journal of physiology. Renal physiology, Vol. 283, Issue 1, pp. F164-72, 2002 (PubMed).

Mounir, Parent: "The expression of neurokinin-1 receptor at striatal and pallidal levels in normal human brain." in: Neuroscience research, Vol. 44, Issue 1, pp. 71-81, 2002 (PubMed).

Kc, Haxhiu, Tolentino-Silva et al.: "Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites." in: Respiratory physiology & neurobiology, Vol. 133, Issue 1-2, pp. 75-88, 2002 (PubMed).

Commons, Connolley, Valentino: "A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 28, Issue 2, pp. 206-15, 2003 (PubMed).

Broccardo, Linari, Agostini et al.: "Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 291, Issue 3, pp. G518-24, 2006 (PubMed).

Alternatives for antigen "Tachykinin Receptor 1 (TACR1)", type "Antibodies"
Hosts (72), (5), (5)
Reactivities (67), (40), (35), (19), (17), (13), (12), (1), (1), (1), (1)
Applications (43), (22), (21), (17), (14), (10), (8), (5), (5), (5), (1)
Conjugates (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)