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Tachykinin Receptor 3 (TACR3) antibody

Antigen

Tachykinin Receptor 3 (TACR3)
Synonyms NK3R, TAC3RL, MGC148060, MGC148061, TACR3, Tacr3
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Guinea Pig
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro))
9 references available
Catalog no. ABIN152452
Quantity 0.15 ml  (1 mg/ml)  (Variants)
Price Product not available in this region.
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Gene ID 6870, 24808
UniProt P16177
Immunogen ABIN152452 was raised against a synthetic peptide at the c-terminus of rat NK-3conjugated to bovine thyroglobulin.
Cross-Reactivity Guinea Pig, Mouse (Murine), Rat (Rattus)
Format Serum
Description The tachykinins belong to an evolutionary conserved family of peptide neurotransmittersthat share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an establishedrole in neurotransmission. The mammalian tachykinins include substance P, neurokininA (NKA) and neurokinin B (NKB) which exert their effects by binding to specificreceptors. Tachykinin peptides are important in the mediation of many physiologicaland pathological processes including inflammation, pain, migraine headache and allergyinduced asthma.Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 whichhave preferential affinities for SP, NKA and NKB respectively. All three receptors sharea high degree of sequence homology, have seven transmembrane spanning domainsand similar signal transduction mechanisms (e.g. G-protein coupled activation ofphospholipase C). Alternate Names: anti-Neurokinin B receptor antibody, anti-Neuromedin K Receptor antibody, anti-NK3receptor antibody, anti-NK3R antibody, anti-TAC3R antibody, anti-TAC3RL antibody,anti-Tachykinin receptor 3 antibody, anti-TACR3 antibody.
Specificity ABIN152452 is specific to the NK-3 receptor. Specificity was verified by the localizationof immunohistochemical staining as well as pre-absorption studies with NK-3 peptide.(1). Species Reactivity: ABIN152452 can be used for detection of NK-3 receptor in rat, mouse and guinea pig inbrain, spinal cord and ileum. (1) Customer feedback suggests that human reactivity isnegative. Localization: In immunohistochemical experiments staining of the neuronal cell bodies and fibers isseen and staining is believed to be localized to the plasma membrane.

Application Details
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Application Notes NB 300-102 can be used in immunohistochemical analysis on frozen and fixed tissuesections.Suggested working dilutions: *Immunohistochemistry (Frozen Sections)1:500-1:1,000Immunohistochemistry (Free-floating sections)1:1,000-1:5,000Western blot(-)*The investigator should determine the optimal dilution for a specific application.
Concentration 1 mg/ml
Purification Serum
Buffer 0.15 ml of anti-NK-3 receptor antisera in PBS with 0.05% Sodium Azide. Phosphate buffered saline
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Research Area Receptors, Neurotransmitters
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Tooney, Au, Chahl: "Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex." in: Neuroscience letters, Vol. 283, Issue 3, pp. 185-8, 2000 (PubMed).

Yip, Chahl: "Localization of NK1 and NK3 receptors in guinea-pig brain." in: Regulatory peptides, Vol. 98, Issue 1-2, pp. 55-62, 2001 (PubMed).

Dick, tom Dieck, Altrock et al.: "The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina." in: Neuron, Vol. 37, Issue 5, pp. 775-86, 2003 (PubMed).

Feigenspan, Janssen-Bienhold, Hormuzdi et al.: "Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 13, pp. 3325-34, 2004 (PubMed).

Howe, Somponpun, Sladek: "Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 45, pp. 10103-10, 2004 (PubMed).

Haley, Flynn: "Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 290, Issue 5, pp. R1242-50, 2006 (PubMed).

Beltran, Hammond, Acland et al.: "A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa." in: Investigative ophthalmology & visual science, Vol. 47, Issue 4, pp. 1669-81, 2006 (PubMed).

Broccardo, Linari, Agostini et al.: "Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 291, Issue 3, pp. G518-24, 2006 (PubMed).

Oh, Khan, Novelli et al.: "Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1679-84, 2007 (PubMed).