Synapsin I (SYN1) (C-Term) antibody

Details for Product No. ABIN152453
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Antigen
Synonyms SYNI, SYN1a, SYN1b, Syn-1, si:dkey-90n12.3, SYN I, Synapsin-1
Epitope
C-Term
(45), (26), (26), (22), (21), (15), (7), (6), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(196), (178), (164), (60), (54), (40), (7), (6), (2), (2), (2), (1)
Host
Rabbit
(224), (13), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(172), (73), (60), (34), (30), (29), (13), (10), (8), (4), (3), (1), (1)
Pubmed 7 references available
Catalog no. ABIN152453
Quantity 10 µg
Price
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Immunogen ABIN152453 was raised against synapsin I purified from bovine brain.
Specificity 300-104 is specific to synapsin I. The specificity is defined based on 300-104's specificimmunolabeling of the synapsin I band in Western blots. This labeling is blocked bysynapsin I preincubation. Species Reactivity: ABIN152453 can be used for detection of Synapsin I in human and rat. Localization: In immunohistochemical experiments, staining with ABIN152453 is most dense in theexternal plexiform layer and glomeruli. Some immunoreactivity is also present in theperiglomerular regions and the deeper layers of the bulb, the olfactory nerve layercontained little immunoreactivity. Both punctate and diffuse immunoreactivity is presentin all layers. (1).
Cross-Reactivity Cow (Bovine), Guinea Pig, Human, Mouse (Murine), Rat (Rattus)
Purification Purified
Alternative Name Synapsin-1
Background Synapsin I (synapsin Ia and Ib, MW ~ 80,000 and 77,000 are collectively referred to assynapsin I) is a neuron specific protein that is localized to nerve terminals. Thesynapsin protein is an excellent marker for synaptic terminals and it can be used toestimate synaptic density and or synaptogenesis. It is thought that synapsin I cross-links synaptic vesicles to the cytoskeleton and therebylimits the ability of these synaptic vesicles to move to active zones and fuse with theplasma membrane during exocytosis. In addition to their role in neurotransmission, the synapsins are also thought to play arole in synapse formation. The appearance of synapsin I immunoreactivity correlatesprecisely with the development of synapses in the CNS. The synapsin protein is anexcellent marker for synaptic terminals and it can be used to estimate synaptic densityand or synaptogenesis. The appearance of synapsin I was a precise indicator ofsynapse formation and that synapsin I immunocytochemistry provides a valuable tool forthe study of synaptogenesis. (2-4). Alternate Names: anti-SYNI antibody, anti-SYN I antibody, anti-SYN1 antibody, anti-SYN1a antibody,anti-SYN 1a antibody, anti-SYN1b antibody, anti-SYN 1b antibody, anti-SynapsinIantibody, anti-Synapsin1 antibody, anti-Synapsin 1 antibody, anti-Brain protein 4.1antibody.
Application Notes Suggested working dilutions: immunohistochemistry 1:2000,immunofluorescence 1:2000,Western Blot 1:1000
Restrictions For Research Use only
Concentration 0.2 mg/ml
Buffer PBS
Storage -20 °C
Supplier Images
anti-Synapsin I (SYN1) (C-Term) antibody Detection of Synapsin1 in rat hippocampal lysate using ABIN152453
General Fletcher, Cameron, De Camilli et al.: "The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 11, Issue 6, pp. 1617-26, 1991 (PubMed).

Moore, Bernstein: "Synaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron microscopy and synapsin I immunoreactivity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 9, Issue 6, pp. 2151-62, 1989 (PubMed).

Stone, Browning, Finger: "Differential distribution of the synapsins in the rat olfactory bulb." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 14, Issue 1, pp. 301-9, 1994 (PubMed).

Danglot, Triller, Bessis: "Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons." in: Molecular and cellular neurosciences, Vol. 23, Issue 2, pp. 264-78, 2003 (PubMed).

Hanus, Ehrensperger, Triller: "Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 17, pp. 4586-95, 2006 (PubMed).

Kennedy, Martin, Ehrhardt et al.: "Requirement of JIP scaffold proteins for NMDA-mediated signal transduction." in: Genes & development, Vol. 21, Issue 18, pp. 2336-46, 2007 (PubMed).

Yang, Yan, Wood: "Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication." in: Journal of virology, Vol. 82, Issue 7, pp. 3590-603, 2008 (PubMed).

Hosts (224), (13), (1)
Reactivities (196), (178), (164), (60), (54), (40), (7), (6), (2), (2), (2), (1)
Applications (172), (73), (60), (34), (30), (29), (13), (10), (8), (4), (3), (1), (1)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (45), (26), (26), (22), (21), (15), (7), (6), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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