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Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) antibody

Antigen

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A)
Synonyms GRIN2A, NMDAR2A, NR2A, nr2a
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
5 references available
Catalog no. ABIN152454
Quantity 10 µg  (0.2 mg/ml)  (Variants)
Price Product not available in this region.
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) antibody

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) antibody (2)

Additional Information
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Alternative name NMDA Receptor 2A
Gene ID 2903, 24409
Immunogen ABIN152454 was raised against a c-terminal fusion protein representing amino acids1253 - 1391of rat NMDAR2A.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description The ion channels activated by glutamate are divided into two classes. Those that aresensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR)while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionicacid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).NMDA receptors are among the most studied receptors in neuroscience because theyare involved in neuronal cell development and plasticity, a cellular correlate for learning.NMDA receptors are also implicated in several disorders of the central nervous systemincluding epilepsy and ischemic neuronal cell death. NMDA receptors also appear to bea target for ethanol at physiological concentrations and therefore may play a significantrole in alcoholism. Alternate Names: anti-Glutamate receptor antibody, anti-GRIN2A antibody, anti-HNR2A antibody, anti-NMethyl D Aspartate Receptor Subtype 2A antibody, anti-NMDA Receptor Type 2Aantibody, anti-NR2A antibody, anti-GRIN 2A antibody, anti-GRIN2A antibody,anti-Glutamate [NMDA] receptor subunit epsilon 1 antibody, anti-Glutamate receptorantibody, anti-Glutamate receptor ionotropic N methyl D aspartate 2A antibody,anti-HNR2A antibody, anti-N Methyl D Aspartate Receptor Subtype 2A antibody, anti-Nmethyl D aspartate receptor subunit 2A antibody, anti-NMDA Receptor Type 2Aantibody, anti-NMDA receptor subtype 2A antibody, anti-NMDAR 2A antibody, anti-NR2A antibody, anti-NR2A antibody, anti-NMDAR2A antibody,.
Specificity 300-105 is specific to NMDAR2A. The specificity is defined based on 300-105's specificimmunolabeling of the 2A subunit band in Western blots. This labeling is blocked bypreincubation with the antigen. Species Reactivity: ABIN152454 can be used for detection of NMDR2A in human and rat. Localization: ABIN152454 can be used to demonstrate that both the NR2A is highly enriched inhippocampus compared to either cortex or cerebellum.

Application Details
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Application Notes Suggested working dilutions: immunohistochemistry 1:1000-1:2000,Western Blot 1:1000
Concentration 0.2 mg/ml
Purification Purified
Buffer 10 ug of affinity purified (lyophilized from ammonium bicarbonate) anti-NMDAR2A.Reconstitute in 50 ul of PBS. n/a
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
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Monyer, Sprengel, Schoepfer et al.: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).

Moriyoshi, Masu, Ishii et al.: "Molecular cloning and characterization of the rat NMDA receptor." in: Nature, Vol. 354, Issue 6348, pp. 31-7, 1991 (PubMed).

Monyer, Burnashev, Laurie et al.: "Developmental and regional expression in the rat brain and functional properties of four NMDA receptors." in: Neuron, Vol. 12, Issue 3, pp. 529-40, 1994 (PubMed).

Laurie, Seeburg: "Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition." in: European journal of pharmacology, Vol. 268, Issue 3, pp. 335-45, 1995 (PubMed).

Ning, Pei, Liao et al.: "Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 16, pp. 4052-60, 2004 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A)", type "Antibodies"
Hosts Rabbit (52), Mouse (5), Goat (1)
Reactivities Human (44), Rat (Rattus) (37), Mouse (Murine) (35), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)
Applications Western Blotting (WB) (32), Immunofluorescence (IF) (28), ELISA (9), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunoprecipitation (IP) (5), Immunocytochemistry (ICC) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunostaining (ISt) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes C-Term (8), pTyr1246 (5), pTyr1325 (4), 2nd Cytoplasmic Domain (2), AA 1099-1213 (1), AA 1265-1464 (1), AA 875-885 (1), Center (1), Cytoplasmic Domain (1), Internal Region (1), N-Term (1), pTyr771 (1)