Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) antibody

Details for Product No. ABIN152455
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms AW490526, GluN2B, NR2B, Nmdar2b, MRD6, NMDAR2B, hNR3, nr2b, nmdar2b
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(290), (278), (257), (139), (136), (135), (70), (17), (8), (7), (4), (3), (3), (2), (2)
Host
Rabbit
(299), (24), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (6), (6), (6), (6), (6), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(195), (96), (90), (90), (44), (41), (37), (20), (19), (11), (4), (2), (1)
Pubmed 8 references available
Catalog no. ABIN152455
Quantity 10 µg
Price
Contact our Customer Service for availability and price in your country.
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen ABIN152455 was raised against a c-terminal fusion protein representing amino acids1253 - 1391 of rat NMDAR2B.
Specificity ABIN152455 is specific to NMDAR 2B. The specificity is defined based on ABIN152455'sspecific immunolabeling of the 2B subunit band in Western blots. This labeling isblocked by preincubation with the antigen. Species Reactivity: ABIN152455 can be used for detection of NMDR2B in human, mouse and rat. Localization: ABIN152455 can be used to demonstrate that the NR2B is highly enriched inhippocampus compared to either cortex or cerebellum.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Purified
Alternative Name NMDAR2B
Background The ion channels activated by glutamate are divided into two classes. Those that aresensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR)while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionicacid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).NMDA receptors are among the most studied receptors in neuroscience because theyare involved in neuronal cell development and plasticity, a cellular correlate for learning.NMDA receptors are also implicated in several disorders of the central nervous systemincluding epilepsy and ischemic neuronal cell death. NMDA receptors also appear to bea target for ethanol at physiological concentrations and therefore may play a significantrole in alcoholism. Alternate Names: anti-NMDAR2B antibody, anti-Glutamate Receptor Ionotropic N Methyl D Aspartate 2Bantibody, anti-Glutamate [NMDA] receptor subunit epsilon 2 antibody, anti-Glutamatereceptor ionotropic NMDA2B antibody, anti-MGC142178 antibody, anti-MGC142180antibody, anti-N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON2 antibody, anti-N methyl D aspartate receptor subtype 2B antibody, anti-N methyl Daspartate receptor subunit 2B antibody, anti-N methyl D aspartate receptor subunit 3antibody, anti-NMDA NR2B antibody, anti-NMDA R2B antibody, anti-NR2B antibody,anti-NR3 antibody, anti-Nmdar2b antibody, anti-hNR 3 antibody, anti-hNR3 antibody,anti-GRIN 2B antibody, anti-GRIN2B antibody, anti-hNR 3 antibody.
Gene ID 2904, 14812, 24410
Research Area Neurology, Neurotransmitters, Receptors
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Concentration 0.2 mg/ml
Buffer PBS. Preservative: No Preservative.
Storage -20 °C
Supplier Images
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) antibody NR2B in rat hippocampus stained with ABIN152455.
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) antibody (2) Lane 1:20 ug of rat brain hippocampus was loaded and ABIN152455 labels a band at 180 kDa. Lanes 2-3: HEK 293 cells expressing NR2A or NR2B respectively. The antibody labels only NR2B and shows no reactivity with NR2A. Non-specific staining of additional bands is seen in HEK293 cells but not in rat brain.
General Monyer, Sprengel, Schoepfer et al.: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).

Moriyoshi, Masu, Ishii et al.: "Molecular cloning and characterization of the rat NMDA receptor." in: Nature, Vol. 354, Issue 6348, pp. 31-7, 1991 (PubMed).

Monyer, Burnashev, Laurie et al.: "Developmental and regional expression in the rat brain and functional properties of four NMDA receptors." in: Neuron, Vol. 12, Issue 3, pp. 529-40, 1994 (PubMed).

Laurie, Seeburg: "Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition." in: European journal of pharmacology, Vol. 268, Issue 3, pp. 335-45, 1995 (PubMed).

Gore: "Gonadotropin-releasing hormone neurons, NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle." in: Brain research. Brain research reviews, Vol. 37, Issue 1-3, pp. 235-48, 2001 (PubMed).

Ning, Pei, Liao et al.: "Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 16, pp. 4052-60, 2004 (PubMed).

Gabra, Kessler, Ritter et al.: "Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia." in: The Journal of pharmacology and experimental therapeutics, Vol. 322, Issue 1, pp. 186-94, 2007 (PubMed).

Bai, Zeng, Hu et al.: "Expression and characteristic of synthetic human epidermal growth factor (hEGF) in transgenic tobacco plants." in: Biotechnology letters, Vol. 29, Issue 12, pp. 2007-12, 2007 (PubMed).

Hosts (299), (24), (5)
Reactivities (290), (278), (257), (139), (136), (135), (70), (17), (8), (7), (4), (3), (3), (2), (2)
Applications (195), (96), (90), (90), (44), (41), (37), (20), (19), (11), (4), (2), (1)
Conjugates (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (6), (6), (6), (6), (6), (1), (1)
Epitopes (42), (38), (35), (26), (22), (22), (17), (16), (7), (6), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
back to top