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tyrosine Hydroxylase (TH) antibody

Details for Product No. ABIN152458, Supplier: Log in to see
Antigen
  • 14-3-3
  • 14-3-3 epsilon
  • 14-3-3-e
  • 14-3-3-epsilon
  • 14-3-3e
  • 14-3-3EPSILON
  • 14-3-3omicron
  • 14-3-30epsilon
  • 143E_DROME
  • 1433epsilon
  • anon-WO0172774.141
  • anon-WO02059370.52
  • CG10118
  • CG31196
  • CT24092
  • D14-3-3e
  • d14-3-3epsilon
  • D14-3-3epsilon
  • DH65B
  • Dmel\\CG10118
  • Dmel\\CG31196
  • DTH
  • dTH1
  • dTH65B
  • DYT5b
  • DYT14
  • EK3-5
  • eps
  • l(3)j2B10
  • Pale
  • pale/ple
  • par-5
  • Par-5
  • PAR-5
  • PAR5
  • Ple
  • SR3-9
  • Su(Raf)3B
  • TH
  • Th
  • th
  • The
  • TYH
  • VII
Reactivity
Human, Mammalian, Mouse (Murine), Rat (Rattus)
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185
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14
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7
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3
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2
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2
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Host
Rabbit
237
50
15
14
8
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
1
1
1
1
1
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1
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1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Western Blotting (WB)
257
160
153
71
47
37
32
26
11
7
4
3
3
2
1
Supplier
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Immunogen SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
Purification Protein A purified
Alternative Name Tyrosine Hydroxylase (TH Antibody Abstract)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation ofthe TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are aconsistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody,anti-Neuronal Marker antibody,.
Gene Symbol: TH
Gene ID 7054
Research Area Amino Acids, Enzymes
Application Notes ICC use reported in literature (see Ramgolam K, et al.). IHC use reported in literature (PMID: 22262884 and PMID: 23811324). Use in Rat & Mouse reported in customer review.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:1000, Immunohistochemistry-Paraffin 1:10-1:500, Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/ml BSA and 50 % glycerol.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
Immunofluorescence (IF) image for anti-tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunohistochemical staining of retina tissue during ABIN152458.
Product cited in: Kunz, Scott, Ittner, Fischer, Born, Vogel: "Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity." in: American journal of physiology. Heart and circulatory physiology, Vol. 293, Issue 4, pp. H2155-60, 2007

Selvage, Lee, Parsons, Seo, Rivier: "A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow." in: Endocrinology, Vol. 145, Issue 4, pp. 1750-9, 2004

Von Coelln, Thomas, Savitt, Lim, Sasaki, Hess, Dawson, Dawson: "Loss of locus coeruleus neurons and reduced startle in parkin null mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10744-9, 2004

Nocjar, Roth, Pehek: "Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group." in: Neuroscience, Vol. 111, Issue 1, pp. 163-76, 2002

Guo, Li, Longhurst: "Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats." in: Neuroscience, Vol. 113, Issue 2, pp. 435-47, 2002

Guo, Lai, Longhurst: "Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat." in: Brain research, Vol. 925, Issue 1, pp. 55-66, 2001

Background publications Kumer, Vrana: "Intricate regulation of tyrosine hydroxylase activity and gene expression." in: Journal of neurochemistry, Vol. 67, Issue 2, pp. 443-62, 1996

Haycock: "Polyvinylpyrrolidone as a blocking agent in immunochemical studies." in: Analytical biochemistry, Vol. 208, Issue 2, pp. 397-9, 1993

Renfroe, Chronister, Haycock, Waymire: "The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: methodological considerations." in: Brain research bulletin, Vol. 13, Issue 1, pp. 109-26, 1984