tyrosine Hydroxylase (TH) antibody

Details for Product No. ABIN152458
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Antigen
Synonyms TYH, DYT14, DYT5b, The, CG10118, DH65B, DTH, Dmel\\CG10118, Pale, Ple, TH, Th, VII, dTH1, dTH65B, pale/ple, th
Reactivity
Human, Mammalian, Mouse (Murine), Rat (Rattus)
(191), (163), (126), (16), (15), (14), (10), (4), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(225), (39), (10), (8), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(228), (124), (119), (84), (51), (50), (45), (30), (21), (5), (4), (4), (1)
Pubmed 9 references available
Catalog no. ABIN152458
Quantity 0.1 mL
Price
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Immunogen Raised aginst SDS denatured rat tyrosine hydroxylase purified frompheochromocytoma.
Specificity ABIN152458 is specific for tyrosine hydroxylase. Species Reactivity: Detects all mammalian forms of TH tested to date and some non-mammalian. Alsodetects some invertebrate forms of TH. Localization: ABIN152458 can be used as a marker for dopaminergic and noradrenergic neurons.
Purification Purified
Alternative Name Tyrosine 3-monooxygenase (TH)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation ofthe TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are aconsistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody,anti-Neuronal Marker antibody,.
Research Area Amino Acids, Enzymes
Application Notes Positive Controls: PC-12 cells stimulated by okadaic acid
Restrictions For Research Use only
Format Liquid
Buffer 10 HEPES [pH7.5], 150 mM NaCl, & 100ug/ml BSA. Preservative: 50% glycerol.
Storage -20 °C
Supplier Images
anti-tyrosine Hydroxylase (TH) antibody Immunohistochemical staining of retina tissue during ABIN152458.
General Renfroe, Chronister, Haycock et al.: "The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: methodological considerations." in: Brain research bulletin, Vol. 13, Issue 1, pp. 109-26, 1984 (PubMed).

Haycock: "Polyvinylpyrrolidone as a blocking agent in immunochemical studies." in: Analytical biochemistry, Vol. 208, Issue 2, pp. 397-9, 1993 (PubMed).

Kumer, Vrana: "Intricate regulation of tyrosine hydroxylase activity and gene expression." in: Journal of neurochemistry, Vol. 67, Issue 2, pp. 443-62, 1996 (PubMed).

Guo, Lai, Longhurst: "Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat." in: Brain research, Vol. 925, Issue 1, pp. 55-66, 2001 (PubMed).

Nocjar, Roth, Pehek: "Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group." in: Neuroscience, Vol. 111, Issue 1, pp. 163-76, 2002 (PubMed).

Guo, Li, Longhurst: "Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats." in: Neuroscience, Vol. 113, Issue 2, pp. 435-47, 2002 (PubMed).

Selvage, Lee, Parsons et al.: "A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow." in: Endocrinology, Vol. 145, Issue 4, pp. 1750-9, 2004 (PubMed).

Von Coelln, Thomas, Savitt et al.: "Loss of locus coeruleus neurons and reduced startle in parkin null mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10744-9, 2004 (PubMed).

Kunz, Scott, Ittner et al.: "Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity." in: American journal of physiology. Heart and circulatory physiology, Vol. 293, Issue 4, pp. H2155-60, 2007 (PubMed).

Hosts (225), (39), (10), (8), (4)
Reactivities (191), (163), (126), (16), (15), (14), (10), (4), (2), (2), (1), (1), (1), (1), (1)
Applications (228), (124), (119), (84), (51), (50), (45), (30), (21), (5), (4), (4), (1)
Conjugates (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Epitopes (43), (34), (32), (18), (16), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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