NMDA Receptor 1 antibody

Details for Product No. ABIN152465
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Antigen
Synonyms CG2902, DMNMDAR1, DNMDAR-I, DNmdar, DmelNmdar1, Dmel\\CG2902, DrNR1, NMDA, NMDA R1, NMDAR1, NMdar1, NR1, NRI, Nmdar, dNR1, dnmdar-I, nmr
Reactivity
Mouse (Murine), Rat (Rattus)
(30), (24), (22), (6), (4), (2), (2), (1)
Host
Rabbit
(32), (3), (2)
Clonality
Polyclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
(29), (9), (8), (5), (4), (3), (2), (2)
Pubmed 2 references available
Quantity 0.025 mg
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Catalog No. ABIN152465
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Immunogen Peptide from the NR1 subunit, C2 splice variant insert of rat NMDA receptor.
Specificity Specific for the ~120k NR1 subunit of the NMDA Receptor containing the C2 splice variant insert. Does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2 insert.
Cross-Reactivity (Details) Tested in Mouse,Rat. Predicted cross-reactivity based on sequence identity: Human (100%).
Purification affinity purified
Background The ion channels activated by glutamate are divided into two classes. Those that aresensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR)while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionicacid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).NMDA receptors are among the most studied receptors in neuroscience because theyare involved in neuronal cell development and plasticity, a cellular correlate for learning.NMDA receptors are also implicated in several disorders of the central nervous systemincluding epilepsy and ischemic neuronal cell death. NMDA receptors also appear to bea target for ethanol at physiological concentrations and therefore may play a significantrole in alcoholism.
Gene Symbol: GRIN2C
Gene ID 2905
Application Notes By Western blot a band is seen at ~120 kDa representing the NMDAR1 C2 splice variant.
Recommended dilutions: Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:1000-1:2000, Western Blot 1:1000
Restrictions For Research Use only
Format Lyophilized
Reconstitution The antibody sho µLd be reconstituted in 50 µL PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4, before use.
Buffer Lyophilized from 5 mM ammonium bicarbonate.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-NMDA Receptor 1 antibody Western blot of 10 ug of HEK 293 cells showing specific immunolabeling of the ~120kDa NR1 subunit of the NMDA receptor containing the C2 splice variant insert.
General Monyer, Sprengel, Schoepfer et al.: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).

Moriyoshi, Masu, Ishii et al.: "Molecular cloning and characterization of the rat NMDA receptor." in: Nature, Vol. 354, Issue 6348, pp. 31-7, 1991 (PubMed).

Validation Images
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