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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Tachykinin Receptor 1 (TACR1) antibody
|Synonyms||SPR, NK1R, NKIR, TAC1R, TACR1|
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
|16 references available|
|Quantity||0.1 ml (1.05 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Gene ID||6869, 24807|
|Immunogen||A peptide derived from the N-terminus of human NK-1 sequence conjugated to KLH.|
|Description||The tachykinins belong to an evolutionary conserved family of peptide neurotransmittersthat share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an establishedrole in neurotransmission. The mammalian tachykinins include substance P, neurokininA (NKA) and neurokinin B (NKB) which exert their effects by binding to specificreceptors. Tachykinin peptides are important in the mediation of many physiologicaland pathological processes including inflammation, pain, migraine headache and allergyinduced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 whichhave preferential affinities for SP, NKA and NKB respectively. All three receptors sharea high degree of sequence homology, have seven transmembrane spanning domainsand similar signal transduction mechanisms (e.g. G-protein coupled activation ofphospholipase C). Alternate Names: anti-NK1 receptor antibody, anti-NK 1 receptor antibody, anti-NK-1 receptor antibody,anti-NK1R antibody, anti-NK 1R antibody, anti-SPR antibody, anti-Substance P receptorantibody, anti-TAC1R antibody, anti-TAC 1R antibody, anti-Tachykinin receptor 1antibody, anti-tachykinin 1 receptor, anti-TACR1 antibody, anti-NK-1r antibody,anti-neurokinin 1 receptor antibody.|
|Specificity||This antibody is specific for human NK-1. Species Reactivity: Human, rat. Localization: Cell Membrane.|
|Application Notes||Immunohistochemistry 10 ug/ml. Positive Controls: SF9 whole cell membrane extracts|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Research Area||Hormones, Receptors|
|Restrictions||For Research Use only|
|Staining of brain, basal nucleus of meynert, neurons using ABIN152468.|
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Mantyh, Pappas, Lapp et al.: "Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum." in: Gastroenterology, Vol. 111, Issue 5, pp. 1272-80, 1996 (PubMed).
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Lai, Ho, Kilpatrick et al.: "Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7771-6, 2006 (PubMed).
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Hazlett, McClellan, Barrett et al.: "Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection." in: Investigative ophthalmology & visual science, Vol. 48, Issue 2, pp. 797-807, 2007 (PubMed).
Schmidtko, Gao, Koenig et al.: "cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 34, pp. 8568-76, 2008 (PubMed).
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