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SLC8A1 antibody (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1) (N-Term)

Details for Product anti-SLC8A1 Antibody No. ABIN152474, Supplier: Log in to see
Antigen
  • AI852629
  • AV344025
  • D930008O12Rik
  • Enx
  • Hox11L.1
  • Hox11l1
  • NCX
  • Ncx
  • Ncx1
  • NCX1
  • ncx1n
  • SLC8A1
  • Tlx1l1
  • Tlx1l2
Epitope
N-Term
16
11
9
2
2
1
1
1
1
Reactivity
Rabbit
30
18
11
9
7
4
1
1
1
1
1
Host
Mouse
37
10
Clonality (Clone)
Monoclonal ()
Conjugate
This SLC8A1 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
43
26
9
5
4
2
2
2
1
Supplier
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Immunogen Fusion protein from the N-terminal region of rabbit renal NaCX
Clone 6H2
Isotype IgG2b
Specificity Specific for the ~120k and 160k Na+/Ca2+ exchanger 1 protein.
Cross-Reactivity (Details) Tested in Rabbit. Canine reactivity reported in scientific literature (PMID: 18025087).rat,reactivity reported in scientific literature (PMID: 22285480). Reactivity assumed based on sequence identity to a wide variety of mammalian species.
Purification Protein G purified
Alternative Name SLC8A1 / NCX1 (SLC8A1 Antibody Abstract)
Background The expression and protein levels of the Na(+)/Ca(2+) exchanger (NCX-1) vary duringheart development and in response to changes in thyroid hormone levels (1). Theexpression of the NCX-1 gene is two-fold higher in the hearts of fetal versus adult mice. In addition, NCX-1 mRNA and protein levels were upregulated in hypothyroidic hearts. In hyperthyroidic hearts this response was reversed, however. Alternate Names: Anti-CNC antibody, Anti-DKFZp779F0871 antibody, Anti-MGC119581 antibody,Anti-Na+/Ca2+ exchange protein 1 antibody, Anti-Na+/Ca2+ exchanger antibody,Anti-NCX 1 antibody, Anti-NCX antibody, Anti-SLC8A1 antibody, Anti-SLC8A1 proteinantibody, Anti-Sodium Calcium Exchanger antibody, Anti-Sodium/calcium exchanger 1antibody, Anti-Solute carrier family 8 member 1 antibody.
Gene Symbol: SLC8A1
Gene ID 6546, 20541, 29715
Application Notes NB300-127 is useful for Western blot and immunohistochemistry. Immunocytochemistry/Immunofluorescence was reported in scientific literature (PMID 22285480). NOTE: One should see a band at ~120 kD in Western Blot. Some tissues have a form that also runs at ~160 kD.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:10-1:2000, Western Blot 1:1000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 50 µL of PBS.
Buffer 0.1mg size: Lyophilized from 5 mM ammonium bicarbonate.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
Western Blotting (WB) image for anti-SLC8A1 antibody (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1) (N-Term) (ABIN152474) Western blot of various tissues showing specific immunolabeling of the ~120k and ~160...
Product cited in: Rapti, Stillitano, Karakikes, Nonnenmacher, Weber, Hulot, Hajjar: "Effectiveness of gene delivery systems for pluripotent and differentiated cells." in: Molecular therapy. Methods & clinical development, Vol. 2, pp. 14067, 2015 (PubMed).

Kho, Lee, Jeong, Oh, Gorski, Fish, Sanchez, DeVita, Christensen, Dahl, Hajjar: "Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure." in: Nature communications, Vol. 6, pp. 7229, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Okamoto, Takano, Ohba, Ono: "Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 5, pp. 988-97, 2012 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunocytochemistry,Immunofluorescence

Vagin, Tokhtaeva, Yakubov, Shevchenko, Sachs: "Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit." in: The Journal of biological chemistry, Vol. 283, Issue 4, pp. 2192-202, 2008 (PubMed). (Sample species: Dog (Canine)). Further details: Western Blotting

Centeno, Díaz de Barboza, Marchionatti, Alisio, Dallorso, Nasif, Tolosa de Talamoni: "Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 139, Issue 2, pp. 133-41, 2004 (PubMed). (Sample species: Chicken).

Sears, Bryant, Ashley, Lygate, Rakovic, Wallis, Neubauer, Terrar, Casadei: "Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling." in: Circulation research, Vol. 92, Issue 5, pp. e52-9, 2003 (PubMed).

Beaugé, Asteggiano, Berberián: "Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger." in: Annals of the New York Academy of Sciences, Vol. 976, pp. 288-99, 2002 (PubMed).

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