Peripherin (PRPH) antibody
| Antigen |
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| Synonyms |
NEF4, PRPH1, Prph1, Perf, nef4, prph1, MGC69454 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Rat (Rattus) (46), Human (45), Mouse (Murine) (29), Dog (Canine) (19), Cow (Bovine) (18), Horse (Equine) (18), Pig (Porcine) (18), Mammalian (9), Cat (Feline) (4), Chicken (3), Rabbit (1)
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Conjugate
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Application
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 Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), ELISA
Western Blotting (WB) (57), Immunofluorescence (IF) (37), Immunocytochemistry (ICC) (20), ELISA (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), Immunohistochemistry (IHC) (11), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)
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| Catalog no. |
ABIN152483 |
| Quantity |
0.1 ml (Variants) |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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Peripherin
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Gene ID
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5630
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Immunogen
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Recombinant full length rat peripherin.
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Cross-Reactivity
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Mammalian
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Format
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Serum
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Description
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Peripherin is a Class III intermediate filament subunit found in both the peripheral andcentral nervous systems, though it is concentrated, as its name suggests, in the neuronsof peripheral ganglia and their processes. Antibodies to peripherin can be used inidentifying, classifying, and studying neurons in the nervous system. Peripherin is alsoa good diagnostic marker for ballooned axons seen in Lou Gehrig's disease and someneuronally derived tumors. Peripherin is also a major component of the cytoskeleton ofPC12 cells, widely used model system for studies of neuronal differentiation.Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes.Peripherin is not related to peripherin-RDS, a photoreceptor protein associated withretinal degeneration and blindness. Alternate Names: anti-NEF4 antibody, anti-neurofilament 4 antibody, anti-Peripherin Variant 61 antibody. Related Diseases: ALS, Diabetes
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Specificity
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Specifically recognizes peripherin, showing no cross reactivity with other Class IIIintermediate filament proteins. Species Reactivity: Human and all other mammalian species to date. Results on avian tissues are howevernot conclusive. Localization: Neuronal Marker.
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Application Notes
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immunofluorescence 1:1000,Western Blot 1:5000
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Purification
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Serum
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Buffer
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0.05 ml of crude rabbit antisera. Contains no preservative.
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Storage
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
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Research Area
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Neurology, Cytoskeleton
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Restrictions
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For Research Use only
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Arvanian, Bowers, Petruska et al.: "Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons." in: Journal of neurophysiology, Vol. 92, Issue 4, pp. 2394-404, 2004 (PubMed).
Burgess, Jucius, Ackerman: "Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 21, pp. 5756-66, 2006 (PubMed).
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Alternatives for antigen "Peripherin (PRPH)", type "Antibodies"
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Hosts
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Rabbit (48), Mouse (16), Chicken (12)
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Reactivities
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Rat (Rattus) (46), Human (45), Mouse (Murine) (29), Dog (Canine) (19), Cow (Bovine) (18), Horse (Equine) (18), Pig (Porcine) (18), Mammalian (9), Cat (Feline) (4), Chicken (3), Rabbit (1)
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Applications
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Western Blotting (WB) (57), Immunofluorescence (IF) (37), Immunocytochemistry (ICC) (20), ELISA (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), Immunohistochemistry (IHC) (11), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)
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Conjugates
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Epitopes
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N-Term (3), C-Term (2), AA 265-471 (1), Internal Region (1)
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2013 BioMed Central Research Awards
