Peripherin (PRPH) antibody

Details for Product No. ABIN152483
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Antigen
Synonyms nef4, prph1, MGC69454, NEF4, PRPH1, Prph1, Perf, if3, plasticin, AOFMD, AVMD, Nmf193, PRPH, RP7, Rd-2, Rd2, Rds, Tspan22, rds
Reactivity
Human, Mammalian, Mouse (Murine), Rat (Rattus)
(76), (57), (29), (15), (14), (14), (12), (4), (1), (1)
Host
Rabbit
(60), (27), (17), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(92), (37), (33), (25), (21), (17), (10), (7), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN152483
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Immunogen Recombinant full length rat Peripherin
Specificity Specifically recognizes peripherin, showing no cross reactivity with other Class III intermediate filament proteins.
Cross-Reactivity (Details) Results on avian tissues are inconclusive.
Purification Whole antisera
Alternative Name Peripherin
Background Peripherin is a Class III intermediate filament subunit found in both the peripheral andcentral nervous systems, though it is concentrated, as its name suggests, in the neuronsof peripheral ganglia and their processes. Antibodies to peripherin can be used inidentifying, classifying, and studying neurons in the nervous system. Peripherin is alsoa good diagnostic marker for ballooned axons seen in Lou Gehrig's disease and someneuronally derived tumors. Peripherin is also a major component of the cytoskeleton ofPC12 cells, widely used model system for studies of neuronal differentiation.Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes.Peripherin is not related to peripherin-RDS, a photoreceptor protein associated withretinal degeneration and blindness. Alternate Names: anti-NEF4 antibody, anti-neurofilament 4 antibody, anti-Peripherin Variant 61 antibody. Related Diseases: ALS, Diabetes
Gene Symbol: PRPH
Gene ID 5630
UniProt P21807
Research Area Neurology, Cytoskeleton
Application Notes This Peripherin antibody can be used for ELISA, Immunocytochemistry/Immunofluorescence and Western blotting. In WB a band can be seen at ~57 kDa. Success in IHC on mouse tissue has been reported in a customer review. Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 16325747) Use in Immunohistochemistry-frozen reported in scientific literature (PMID 24277578)
Recommended dilutions: ELISA 1:100-1:2000, Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry 1:500, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot 1:5000
Restrictions For Research Use only
Format Liquid
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
anti-Peripherin (PRPH) antibody Detection of the 57 kDa peripherin protein in whole rat brain stem homogenate using ABIN152483 (1:20,000). The faint 48 kDa band is a peripherin molecule.
General Arvanian, Bowers, Petruska et al.: "Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons." in: Journal of neurophysiology, Vol. 92, Issue 4, pp. 2394-404, 2004 (PubMed).

Burgess, Jucius, Ackerman: "Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 21, pp. 5756-66, 2006 (PubMed).

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