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Details for Product No. ABIN152518

tyrosine Hydroxylase (TH) (pSer40) antibody

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Synonyms TYH, DYT14, DYT5b, The, CG10118, DH65B, DTH, Dmel\\CG10118, Pale, Ple, TH, Th, VII, dTH1, dTH65B, pale/ple, th
»Alternatives pSer40
»Alternatives Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152518
Quantity 0.1 mL
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Immunogen A synthetic phosphopeptide corresponding to residues surrounding the phosphorylatedSer40 of rat Tyrosine Hydroxylase (TH). [Swiss-Prot# P04177].
Specificity ABIN152518 is specific for the 60 kDa Tyrosine Hydroxylase phosphorylated at Ser40.Phosphorylated:Ser40. Species Reactivity: Rat, human, pig, quail, monkey and mouse. Other species have not been tested.
Purification Purified
Alternative Name Tyrosine 3-monooxygenase (TH)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore, the regulationof the TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson',s disease is also considered a TH deficiency, as low dopamine levelsare a consistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody. Related Diseases: Manic depression, Schizophrenia, Parkinson',s disease
Gene ID 7054, 21823, 25085
Research Area Amino Acids, Enzymes, Phospho-specific antibodies
Application Notes Suggested working dilutions: immunohistochemistry 1:1,000,immunofluorescence 1:1,000,Western Blot 1:1,000 (ECL)
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/ml
Buffer PBS (divalent-deficient) containing 10% glyverol, 10 mM HEPES [pH 7.2], 20 mMTris-HCl [pH 7.6], 1 m
Storage -20 °C
Lew, Garcia-Espana, Lee et al.: "Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity." in: Molecular pharmacology, Vol. 55, Issue 2, pp. 202-9, 1999 (PubMed).

Salvatore, Garcia-Espana, Goldstein et al.: "Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds." in: Journal of neurochemistry, Vol. 75, Issue 1, pp. 225-32, 2000 (PubMed).

Witkovsky, Gabriel, Haycock et al.: "Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina." in: Journal of chemical neuroanatomy, Vol. 19, Issue 2, pp. 105-16, 2000 (PubMed).

Alternatives for antigen "tyrosine Hydroxylase (TH)", type "Antibodies"
Hosts (205), (33), (11), (7), (5)
Reactivities (184), (142), (115), (18), (15), (14), (10), (2), (2), (2), (1), (1), (1), (1)
Applications (202), (122), (94), (71), (48), (43), (38), (30), (20), (11), (8), (8), (4)
Conjugates (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Epitopes (41), (33), (25), (17), (16), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)