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Details for Product No. ABIN152544

Huntingtin Interacting Protein 1 (HIP1) antibody

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Synonyms HIP-I, ILWEQ, 2610109B09Rik, A930014B11Rik, E130315I21Rik, mKIAA4113, CG10971, Dmel\\CG10971, Hip1R, hip1, MGC78813
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN152544
Quantity 0.1 mL
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Immunogen Human 3'-HIP1 (~65 kDa).
Clone 4B10
Isotype IgG
Specificity Species Reactivity: Human. Does not react with rat protein. Other species have not been tested. Localization: Cytoplasm.
Cross-Reactivity Human
Purification Ascites
Alternative Name HIP1
Background Huntingtin disease, a neurodegenerate disease, is caused by the expansion of apolymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) isa reportedly proapoptotic, cargo-specific adaptor protein that may be involved in thepathogenesis of Huntingtin disease. In addition to playing a role in Huntingtin disease, itis likely to be involved in the recruitment of clathrin coats to lipid membranes and it mayalso factor in tumorigenesis by allowing the survival of precancerous and cancerouscells. Since HIP-1 expression is significantly associated with prostate and colon cancermetastasis, HIP-1 can serve as a putative prognostic factor for prostate and coloncancers. Alternate Names: anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody.
Gene ID 3092, 192154
UniProt O00291
Application Notes Suggested working dilutions: Western Blot - 1:10,000
Restrictions For Research Use only
Format Liquid
Concentration 58 mg/ml
Buffer 0.1 ml of mouse ascites (58 mg/ml) in PBS and 0.1% Sodium Azide.
Preservative Sodium azide
Storage -20 °C
Rao, Chang, Kumar et al.: "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors." in: Molecular and cellular biology, Vol. 21, Issue 22, pp. 7796-806, 2001 (PubMed).

Rao, Hyun, Kumar et al.: "Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival." in: The Journal of clinical investigation, Vol. 110, Issue 3, pp. 351-60, 2002 (PubMed).

Hyun, Rao, Saint-Dic et al.: "HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14294-306, 2004 (PubMed).

Mills, Gaughan, Robson et al.: "Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors." in: The Journal of cell biology, Vol. 170, Issue 2, pp. 191-200, 2005 (PubMed).

Alternatives for antigen "Huntingtin Interacting Protein 1 (HIP1)", type "Antibodies"
Hosts (31), (17)
Reactivities (46), (16), (16), (12), (12)
Applications (39), (15), (11), (10), (4), (3), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (1)