Huntingtin Interacting Protein 1 (HIP1) antibody

Details for Product No. ABIN152545
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Synonyms HIP-I, ILWEQ, 2610109B09Rik, A930014B11Rik, E130315I21Rik, mKIAA4113, CG10971, Dmel\\CG10971, Hip1R, hip1, MGC78813
Human, Mouse (Murine)
(48), (17), (15), (12), (12)
(28), (22)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(38), (17), (10), (10), (5), (4), (3), (1)
Pubmed 3 references available
Catalog no. ABIN152545
Quantity 0.1 mL
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Immunogen Human 3'-HIP1 (~65 kDa).
Clone 1B11
Isotype IgG1
Specificity ABIN152545 is specific for human HIP1. Does not cross-react with HIP1r.Localization:. Species Reactivity: ABIN152545 recognizes human. It does not appear to work in rat. Other species havenot been tested. Localization: Cytoplasmic.
Cross-Reactivity Human
Purification Ascites
Alternative Name HIP1
Background Huntingtin disease, a neurodegenerate disease, is caused by the expansion of apolymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) isa reportedly proapoptotic, cargo-specific adaptor protein that may be involved in thepathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it islikely to be involved in the recruitment of clathrin coats to lipid membranes and it mayalso factor in tumorigenesis by allowing the survival of precancerous and cancerouscells. Since HIP-1 expression is significantly associated with prostate and colon cancermetastasis, HIP-1 can serve as a putative prognostic factor for prostate and coloncancers. Alternate Names: anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody.
Gene ID 3092, 192154
UniProt O00291
Application Notes Suggested working dilutions: Western Blot 1:10000. Positive Controls: HeLa whole cell lysate
Restrictions For Research Use only
Format Liquid
Concentration 40.8 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
General Rao, Chang, Kumar et al.: "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors." in: Molecular and cellular biology, Vol. 21, Issue 22, pp. 7796-806, 2001 (PubMed).

Rao, Hyun, Kumar et al.: "Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival." in: The Journal of clinical investigation, Vol. 110, Issue 3, pp. 351-60, 2002 (PubMed).

Mills, Gaughan, Robson et al.: "Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors." in: The Journal of cell biology, Vol. 170, Issue 2, pp. 191-200, 2005 (PubMed).

Hosts (28), (22)
Reactivities (48), (17), (15), (12), (12)
Applications (38), (17), (10), (10), (5), (4), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (1)
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