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tyrosine Hydroxylase (TH) (Ser19) antibody

Details for Product No. ABIN152553, Supplier: Log in to see
Antigen
  • CG10118
  • DH65B
  • DTH
  • Dmel\\CG10118
  • Pale
  • Ple
  • TH
  • Th
  • VII
  • dTH1
  • dTH65B
  • pale/ple
  • th
  • 14-3-3
  • 14-3-3 epsilon
  • 14-3-3-e
  • 14-3-3-epsilon
  • 14-3-30epsilon
  • 14-3-3EPSILON
  • 14-3-3e
  • 14-3-3omicron
  • 1433epsilon
  • 143E_DROME
  • CG31196
  • CT24092
  • D14-3-3e
  • D14-3-3epsilon
  • Dmel\\CG31196
  • EK3-5
  • PAR-5
  • PAR5
  • Par-5
  • SR3-9
  • Su(Raf)3B
  • anon-WO0172774.141
  • anon-WO02059370.52
  • d14-3-3epsilon
  • eps
  • l(3)j2B10
  • par-5
  • DYT14
  • DYT5b
  • TYH
  • The
Epitope
Ser19
48
36
32
27
18
13
5
5
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
210
183
117
19
13
10
6
5
3
3
2
2
2
1
1
1
1
Host
Rabbit
237
49
15
13
8
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
254
159
152
70
47
37
32
25
12
6
4
3
3
2
Supplier
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Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser19 conjugated to KLH
Specificity Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser19.
Cross-Reactivity (Details) Reactivity assumed based on sequence identity to a wide variety of mammalian species.
Purification Immunogen affinity purified
Alternative Name Tyrosine 3-monooxygenase (TH) (TH Antibody Abstract)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation ofthe TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are aconsistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody.
Gene Symbol: TH
Gene ID 7054
Pathways
Application Notes NB 300-212 can be used in Western blot, Immunohistochemistry and Immunofluorescence.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Frozen 1:1000, Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer 10 mM HEPES [pH 7.5] contains 10 mM NaCl, 0.1 mg/ml BSA and 50 % glycerol
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
Western Blotting (WB) image for anti-tyrosine Hydroxylase (TH) (Ser19) antibody (ABIN152553) anti-tyrosine Hydroxylase (TH) (Ser19) antibody
Product cited in: Kim, Fan, Gabbi et al.: "Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 6, pp. 2094-9, 2008 (PubMed).

Andres-Mateos, Perier, Zhang et al.: "DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 37, pp. 14807-12, 2007 (PubMed).

Witkovsky, Gabriel, Haycock et al.: "Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina." in: Journal of chemical neuroanatomy, Vol. 19, Issue 2, pp. 105-16, 2000 (PubMed).