tyrosine Hydroxylase (TH) (Ser19) antibody

Details for Product No. ABIN152553
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
CG10118, DH65B, DTH, Dmel\\CG10118, Pale, Ple, TH, Th, VII, dTH1, dTH65B, pale/ple, th, 14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-30epsilon, 14-3-3EPSILON, 14-3-3e, 14-3-3omicron, 1433eps ... show more
CG10118, DH65B, DTH, Dmel\\CG10118, Pale, Ple, TH, Th, VII, dTH1, dTH65B, pale/ple, th, 14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-30epsilon, 14-3-3EPSILON, 14-3-3e, 14-3-3omicron, 1433epsilon, 143E_DROME, CG31196, CT24092, D14-3-3e, D14-3-3epsilon, Dmel\\CG31196, EK3-5, PAR-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, d14-3-3epsilon, eps, l(3)j2B10, par-5, DYT14, DYT5b, TYH, The show less
Epitope
Ser19
(49), (39), (38), (26), (16), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(195), (174), (129), (15), (14), (14), (8), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(240), (36), (12), (9), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
(241), (142), (129), (72), (52), (39), (39), (30), (23), (9), (6), (4), (2)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN152553
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser19 conjugated to KLH
Specificity Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser19.
Cross-Reactivity (Details) Reactivity assumed based on sequence identity to a wide variety of mammalian species.
Purification Immunogen affinity purified
Alternative Name Tyrosine 3-monooxygenase (TH)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation ofthe TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are aconsistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody.
Gene Symbol: TH
Gene ID 7054
Application Notes NB 300-212 can be used in Western blot, Immunohistochemistry and Immunofluorescence.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Frozen 1:1000, Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer 10 mM HEPES [pH 7.5] contains 10 mM NaCl, 0.1 mg/ml BSA and 50 % glycerol
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-tyrosine Hydroxylase (TH) (Ser19) antibody anti-tyrosine Hydroxylase (TH) (Ser19) antibody
General Witkovsky, Gabriel, Haycock et al.: "Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina." in: Journal of chemical neuroanatomy, Vol. 19, Issue 2, pp. 105-16, 2000 (PubMed).

Andres-Mateos, Perier, Zhang et al.: "DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 37, pp. 14807-12, 2007 (PubMed).

Kim, Fan, Gabbi et al.: "Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 6, pp. 2094-9, 2008 (PubMed).

Validation Images
Did you look for something else?
back to top