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Details for Product No. ABIN152553

tyrosine Hydroxylase (TH) (pSer19) antibody

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Synonyms TYH, DYT14, DYT5b, The, CG10118, DH65B, DTH, Dmel\\CG10118, Pale, Ple, TH, Th, VII, dTH1, dTH65B, pale/ple, th
»Alternatives pSer19
»Alternatives Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152553
Quantity 0.1 mL
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Immunogen ABIN152553 was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylatedSer19 of rat Tyrosine Hydroxylase (TH).
Specificity ABIN152553 is specific for the 60 kDa Tyrosine Hydroxylase phosphorylated at Ser19 inlysates of PC12 cells, stimulated by okadaic acid. See reference.Phosphorylated:Ser19. Species Reactivity: Rat.
Purification Affinity Purified
Alternative Name Tyrosine 3-monooxygenase (TH)
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of thecatecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation ofthe TH enzyme represents the central means for controlling the synthesis of theseimportant catecholamines. TH has a large molecular diversity, resulting from differentialsplicing of its mRNA, which is tissue specific and might result in long term changes inactivity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility tovarious disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are aconsistent neurochemical abnormality. Alternate Names: anti-TH antibody, anti-Tyrosine hydroxylase antibody, anti-Tyrosine 3-monooxygenaseantibody, anti-L-tyrosine hydroxylase antibody, anti-Tyrosine 3-hydroxylase antibody.
Application Notes Suggested working dilutions: immunohistochemistry 1:1000,immunofluorescence 1:1000,Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/ml
Buffer Preservative: No preservative.
Storage -20 °C
Witkovsky, Gabriel, Haycock et al.: "Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina." in: Journal of chemical neuroanatomy, Vol. 19, Issue 2, pp. 105-16, 2000 (PubMed).

Andres-Mateos, Perier, Zhang et al.: "DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 37, pp. 14807-12, 2007 (PubMed).

Kim, Fan, Gabbi et al.: "Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 6, pp. 2094-9, 2008 (PubMed).

Alternatives for antigen "tyrosine Hydroxylase (TH)", type "Antibodies"
Hosts (206), (33), (11), (7), (4)
Reactivities (185), (143), (116), (18), (15), (14), (10), (2), (2), (2), (1), (1), (1), (1)
Applications (202), (122), (94), (71), (48), (43), (38), (30), (20), (11), (8), (8), (4)
Conjugates (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Epitopes (42), (33), (24), (17), (14), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)