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Details for Product No. ABIN152574

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) (pSer75) antibody

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Synonyms Darpp32, AU040756, DARPP-32, DARPP32, Darpp-32, darpp32, darpp-32
»Alternatives pSer75
»Alternatives Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN152574
Quantity 0.1 mL
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Immunogen Synthetic phosphopeptide corresponding to amino acids residues surrounding thephospho Thr75 of DARPP-32. The sequence of the immunogen is identical in humanand mouse.
Specificity Specific for the ~34k DARPP-32 phosphorylated at Thr75. Phosphorylated:Thr75. Species Reactivity: Reacts with human, mouse, rat, bovine, canine, chicken, and primate. Localization: Cytoplasmic.
Cross-Reactivity Human, Mouse (Murine)
Purification Affinity Purified
Alternative Name DARPP32
Background DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associatedwith dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The proteininhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, whenDARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation ofdopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thoughtto play important roles in the actions of alcohol, caffeine and Prozac. Alternate Names: anti-DARPP 32 antibody, anti-DARPP32 antibody, anti-Dopamine- and cAMP-regulatedneuronal phosphoprotein antibody.
Gene ID 84152, 19049, 360616
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Buffer 0.1 ml affinity purified antibody in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mlBSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blot.
Storage -20 °C
Maldve, Zhang, Ferrani-Kile et al.: "DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens." in: Nature neuroscience, Vol. 5, Issue 7, pp. 641-8, 2002 (PubMed).

Lindskog, Svenningsson, Pozzi et al.: "Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine." in: Nature, Vol. 418, Issue 6899, pp. 774-8, 2002 (PubMed).

Svenningsson, Tzavara, Carruthers et al.: "Diverse psychotomimetics act through a common signaling pathway." in: Science (New York, N.Y.), Vol. 302, Issue 5649, pp. 1412-5, 2003 (PubMed).

Han, Han, Tiwari et al.: "Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP." in: The Journal of cell biology, Vol. 176, Issue 1, pp. 101-11, 2007 (PubMed).

Alternatives for antigen "Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B)", type "Antibodies"
Hosts (125), (6), (2), (2)
Reactivities (115), (101), (89), (51), (49), (36), (36), (12), (4), (4), (2), (1), (1)
Applications (97), (45), (35), (30), (22), (21), (8), (6), (3), (2), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (37), (28), (11), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)