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Details for Product No. ABIN152590

Notch 1 (NOTCH1) antibody

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Synonyms hN1, TAN1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, NOTCH, Xotch, notch, notch-1, notch1-a, xnotch, xnotch1, notch1, NOTCH1, hn1, tan1, xotch
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152590
Quantity 0.2 mL
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Immunogen A synthetic peptide corresponding to amino acid residues of human Notch 1 locatednear the N-terminal sequence of the cleaved N intracellular domain (NICD).
Specificity Notch-1 does not react with mouse N2, N3, or N4. It only recognizes the cleavedintracellular (activated) form (NICD). Species Reactivity: Reacts with human, mouse, and rat.
Cross-Reactivity Human, Mouse (Murine)
Purification Serum
Alternative Name NOTCH1
Background Notch is synthesized in the endoplasmic reticulum as an inactive form which isproteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi networkbefore it reaches the plasma membrane to yield an active, ligand-accessible form.Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC).Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme(TACE) to yield a membrane-associated intermediate fragment called Notchextracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependentgamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from themembrane which then translocates to the nucleus to activate transcription ofdownstream genes. Alternate Names: anti-Notch1 antibody, anti-Notch-1 antibody, anti-TAN1 antibody, anti-TranslocationAssociated Notch Homolog antibody, anti-Neurogenic locus Notch homolog protein 1antibody, anti-hN1 antibody.
Gene ID 4851, 18128, 25496
Research Area Receptors, Signaling, Inflammation, Immunology
Application Notes Suggested working dilutions: ELISA - 1:20,000-1:60,000,Western Blot - 1:500
Restrictions For Research Use only
Format Liquid
Buffer 0.02 M potassium phosphate, 0.15 M sodium chloride, [pH7.2]. Preservative: 0.1% Sodium azide.
Preservative Sodium azide
Storage 4 °C
Bertrand, Eckfeldt, Lysholm et al.: "Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells." in: Leukemia, Vol. 14, Issue 12, pp. 2095-102, 2001 (PubMed).

Gridley: "Notch signaling and inherited disease syndromes." in: Human molecular genetics, Vol. 12 Spec No 1, pp. R9-13, 2003 (PubMed).

Milano, McKay, Dagenais et al.: "Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 82, Issue 1, pp. 341-58, 2004 (PubMed).

Alternatives for antigen "Notch 1 (NOTCH1)", type "Antibodies"
Hosts (84), (62), (5), (5), (3), (2)
Reactivities (119), (75), (28), (4), (2), (1), (1), (1), (1), (1)
Applications (90), (53), (40), (40), (27), (12), (10), (10), (5), (4), (2), (2), (2)
Conjugates (9), (7), (2), (1), (1), (1), (1), (1)
Epitopes (12), (9), (6), (5), (5), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)