Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

Details for Product No. ABIN152608
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms PARK8, RIPK7, ROCO2, AURA17, DARDARIN, Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, LRRK2
Reactivity
Cow (Bovine), Human, Mouse (Murine)
(135), (73), (72), (34), (13), (13), (2)
Host
Rabbit
(97), (50), (5), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(127), (45), (39), (36), (33), (20), (15), (12), (11), (8), (2), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN152608
Quantity 0.1 mL
Price
Contact our Customer Service for availability and price in your country.
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A C-terminal synthetic peptide made to the human LRRK2 protein sequence (betweenresidues 2500-2527).
Specificity ABIN152608 reacts with LRRK2. Species Reactivity: Reacts with human and bovine. Does not react with mouse. There is 87% sequenceidentity with rat protein. 94% sequence identity with mouse protein. Localization: Mitochondrial outer membrane.
Cross-Reactivity Cow (Bovine), Human
Purification Purified
Alternative Name PARK8 / LRRK2
Background This gene is a member of the leucine-rich repeat kinase family and encodes a proteinwith an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, aDFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40domain. The protein is present largely in the cytoplasm but also associates with themitochondrial outer membrane. Mutations in this gene have been associated withParkinson disease-8. Alternate Names: anti-LRRK-2 antibody, anti-LRRK 2 antibody, anti-PARK8 antibody, anti-ROCO2antibody, anti-Dardarin antibody, anti-BC 300-268 antibody. Related Diseases: Parkinson',s Disease, Lewy Body Disease
Gene ID 120892, 66725
UniProt Q5S007
Application Notes WB: (the theoretical molecular weight of LRRK2 is ~286 kDa. We have also seen otherbands with some lysates, but these bands have been blocked by the control peptide,suggesting that these bands are degredation products). Has also been used to immunoprecipitate LRRK2 in an LRRK2 autophosphorylation kinase assay.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer This antibody is supplied as 0.1 ml of purified antibody [1 mg/ml] inTris-citrate/phosphate [pH 7-8] containing 0.1% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody Detection of LRRK2 in HeLa whole cell lysate (RIPA) using ABIN152608. 1:5,000 dilution, 1 minute ECL detection.
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (2) Detection of LRRK2 in 50 ug of crude bovine brain membrane using ABIN152608.
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (3) Mouse CAD cells transfected with Human wild-type LRRK-2 (1:2,000)
General Miklossy, Arai, Guo et al.: "LRRK2 expression in normal and pathologic human brain and in human cell lines." in: Journal of neuropathology and experimental neurology, Vol. 65, Issue 10, pp. 953-63, 2006 (PubMed).

Melrose, Kent, Taylor et al.: "A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease." in: Neuroscience, Vol. 147, Issue 4, pp. 1047-58, 2007 (PubMed).

Hosts (97), (50), (5), (3), (1)
Reactivities (135), (73), (72), (34), (13), (13), (2)
Applications (127), (45), (39), (36), (33), (20), (15), (12), (11), (8), (2), (1), (1), (1), (1)
Conjugates (7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (20), (18), (18), (12), (12), (8), (6), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top