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Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

Antigen

Leucine-Rich Repeat Kinase 2 (LRRK2)
Synonyms Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, PARK8, RIPK7, ROCO2, AURA17, DARDARIN, LRRK2
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Cow (Bovine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
3 references available
Catalog no. ABIN152609
Quantity 25 µl  (1 mg/ml)  (Variants)
Price Product not available in this region.
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anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (2)

anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (3)

Additional Information
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Alternative name PARK8 / LRRK2
Gene ID 120892
Immunogen A C-terminal synthetic peptide made to the human LRRK2 protein sequence (betweenresidues 2500-2527).
Cross-Reactivity Cow (Bovine), Human
Description LRRK2 is a 286 kDa protein belonging to the ROCO family. It is a multifunction proteininvolved in Parkinson's disease. Alternate Names: anti-LRRK-2 antibody, anti-LRRK 2 antibody, anti-PARK8 antibody, anti-ROCO2antibody, anti-Dardarin antibody, anti-BC 300-268 antibody.
Specificity ABIN152608 reacts with LRRK2. Species Reactivity: Human and bovine. Negative in mouse. Other species have not been tested. There is87% homology of the immunogen with the mouse and rat LRRK2 proteins. Localization: Mitochondrial outer membrane.

Application Details
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Application Notes Suggested working dilutions: immunofluorescence 1:2,000 ,Western Blot 1:1,000~1:10,000
Concentration 1 mg/ml
Purification Aff - Purified
Buffer Tris-citrate/phosphate [pH 7-8]. Preservative: 0.1% Sodium Azide.
Storage Store at 4C. Do not freeze.
Restrictions For Research Use only

Publications
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Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).

Miklossy, Arai, Guo et al.: "LRRK2 expression in normal and pathologic human brain and in human cell lines." in: Journal of neuropathology and experimental neurology, Vol. 65, Issue 10, pp. 953-63, 2006 (PubMed).

Melrose, Kent, Taylor et al.: "A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease." in: Neuroscience, Vol. 147, Issue 4, pp. 1047-58, 2007 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Leucine-Rich Repeat Kinase 2 (LRRK2)", type "Antibodies"
Hosts Rabbit (74), Mouse (11), Goat (5), Sheep (3)
Reactivities Human (85), Mouse (Murine) (43), Cow (Bovine) (38), Rat (Rattus) (37), Dog (Canine) (18), Horse (Equine) (18), Pig (Porcine) (18), Rabbit (18)
Applications Western Blotting (WB) (59), Immunofluorescence (IF) (37), ELISA (35), Immunohistochemistry (IHC) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunoprecipitation (IP) (4), Immunostaining (ISt) (4), Immunoelectron Microscopy (IEM) (3), Immunocytochemistry (ICC) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1), Radioimmunoassay (RIA) (1)
Conjugates Biotin (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes pThr1410 (18), C-Term (8), Glu519 (2), Leu893 (2), Leu899 (2), Leu955 (2), N-Term (2), AA 1838-2133 (1), AA 2506-2522 (1), AA 945-960 (1), AA 946-962 (1), Internal Region (1)