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Details for Product No. ABIN152609

Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

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Antigen
Synonyms PARK8, RIPK7, ROCO2, AURA17, DARDARIN, Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, LRRK2
Reactivity
»Alternatives Cow (Bovine), Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN152609
Quantity 25 µL
Price
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Immunogen A C-terminal synthetic peptide made to the human LRRK2 protein sequence (betweenresidues 2500-2527).
Specificity ABIN152608 reacts with LRRK2. Species Reactivity: Human and bovine. Negative in mouse. Other species have not been tested. There is87% homology of the immunogen with the mouse and rat LRRK2 proteins. Localization: Mitochondrial outer membrane.
Cross-Reactivity Cow (Bovine), Human
Purification Affinity Purified
Alternative Name PARK8 / LRRK2
Background LRRK2 is a 286 kDa protein belonging to the ROCO family. It is a multifunction proteininvolved in Parkinson's disease. Alternate Names: anti-LRRK-2 antibody, anti-LRRK 2 antibody, anti-PARK8 antibody, anti-ROCO2antibody, anti-Dardarin antibody, anti-BC 300-268 antibody.
Gene ID 120892
Application Notes Suggested working dilutions: immunofluorescence 1:2,000 ,Western Blot 1:1,000~1:10,000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate [pH 7-8]. Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).

Miklossy, Arai, Guo et al.: "LRRK2 expression in normal and pathologic human brain and in human cell lines." in: Journal of neuropathology and experimental neurology, Vol. 65, Issue 10, pp. 953-63, 2006 (PubMed).

Melrose, Kent, Taylor et al.: "A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease." in: Neuroscience, Vol. 147, Issue 4, pp. 1047-58, 2007 (PubMed).

Alternatives for antigen "Leucine-Rich Repeat Kinase 2 (LRRK2)", type "Antibodies"
Hosts (120), (49), (8), (4)
Reactivities (159), (90), (73), (39), (15), (13), (2)
Applications (144), (48), (46), (44), (39), (24), (20), (17), (17), (8), (2), (2), (1), (1), (1)
Conjugates (9), (9), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (20), (18), (18), (12), (12), (8), (6), (5), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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