Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

Details for Product No. ABIN152609
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Antigen
Synonyms PARK8, RIPK7, ROCO2, AURA17, DARDARIN, Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, LRRK2
Reactivity
Cow (Bovine), Human, Mouse (Murine)
(135), (73), (72), (34), (13), (13), (2)
Host
Rabbit
(97), (50), (5), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(127), (45), (39), (36), (33), (20), (15), (12), (11), (8), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN152609
Quantity 25 µL
Price
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Immunogen A C-terminal synthetic peptide made to the human LRRK2 protein sequence (betweenresidues 2500-2527).
Specificity ABIN152608 reacts with LRRK2. Species Reactivity: Human and bovine. Negative in mouse. Other species have not been tested. There is87% homology of the immunogen with the mouse and rat LRRK2 proteins. Localization: Mitochondrial outer membrane.
Cross-Reactivity Cow (Bovine), Human
Purification Affinity Purified
Alternative Name PARK8 / LRRK2
Background LRRK2 is a 286 kDa protein belonging to the ROCO family. It is a multifunction proteininvolved in Parkinson's disease. Alternate Names: anti-LRRK-2 antibody, anti-LRRK 2 antibody, anti-PARK8 antibody, anti-ROCO2antibody, anti-Dardarin antibody, anti-BC 300-268 antibody.
Gene ID 120892
Application Notes Suggested working dilutions: immunofluorescence 1:2,000 ,Western Blot 1:1,000~1:10,000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate [pH 7-8]. Preservative: 0.1% Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody Detection of LRRK2 in HeLa whole cell lysate (RIPA) using ABIN152608. 1:5,000 dilution, 1 minute ECL detection.
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (2) Detection of LRRK2 in 50 ug of crude bovine brain membrane using ABIN152608.
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody (3) Mouse CAD cells transfected with Human wild-type LRRK-2 (1:2,000)
General Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).

Miklossy, Arai, Guo et al.: "LRRK2 expression in normal and pathologic human brain and in human cell lines." in: Journal of neuropathology and experimental neurology, Vol. 65, Issue 10, pp. 953-63, 2006 (PubMed).

Melrose, Kent, Taylor et al.: "A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease." in: Neuroscience, Vol. 147, Issue 4, pp. 1047-58, 2007 (PubMed).

Hosts (97), (50), (5), (3), (1)
Reactivities (135), (73), (72), (34), (13), (13), (2)
Applications (127), (45), (39), (36), (33), (20), (15), (12), (11), (8), (2), (1), (1), (1), (1)
Conjugates (7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (20), (18), (18), (12), (12), (8), (6), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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