Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (Ser33), (Ser37) antibody

Details for Product No. ABIN152613
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Antigen
Synonyms Jup, LOC100217813, CTNNB1, CTNNB, Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, ctnnb1, CHBCAT, MRD19, armadillo, beta-catenin
Epitope
Ser33, Ser37
(62), (19), (19), (19), (16), (15), (11), (9), (8), (6), (6), (6), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(381), (105), (87), (14), (12), (11), (4), (4), (4), (4), (3), (1), (1)
Host
Rabbit
(280), (124), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (4), (4), (3), (3), (3), (1), (1)
Application
Western Blotting (WB)
(369), (148), (102), (91), (79), (78), (54), (39), (25), (7), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN152613
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Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33,Ser37 conjugated to KL
Specificity Specific for the ~83k beta-catenin phosphorylated at Ser33 and Ser37.
Cross-Reactivity (Details) Tested in Human. Reactivity assumed based on 100% sequence identity: Mouse, Rat,Xenopus.
Purification Immunogen affinity purified
Alternative Name CTNNB1 / Beta Catenin
Background B-Catenin is a central component of the cadherin cell adhesion complex and plays anessential role in neural development in the Wingless/Wnt signaling pathway (Ding andDale, 2002, Polakis, 2000). The role of B-catenin in these processes is thoughtregulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 byglycogen synthase kinase 3B (GSK3B) (Liu et al, 2002). This hyperphosphorylationpromotes the ubiquitylation and targeted destruction of B-catenin. Mutations incomponents of this phosphorylation regulated process that prevent B-cateninhyperphosphorylation by GSK3B are strongly associated with cancers (Wang et al,2003, Polakis, 2000, Liu et al, 2002). Alternate Names: anti-Beta-Catenin antibody, anti-B-Catenin antibody, anti-CTNNB antibody.
Gene Symbol: CTNNB1
Gene ID 1499, 84353
Application Notes Recommended dilutions: Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES [pH 7.5], 150 mM NaCl, 0.1 mg/ml BSA and 50 % glycerol
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (Ser33), (Ser37) antibody Western Blot of human embryonic kidney cell (HEK) lysate showing immunolabeling with the phospho-specific Ser33,37 B-catenin antibody, ABIN152613 (upper panel) and a pan B-catenin (lower panel). Control is a standard HEK cell lysates. GSK3 is a HEK cell lysate with glycogen synthase kinase 3B knocked down by SiRNA.
General Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).

Ding, Dale: "Wnt signal transduction: kinase cogs in a nano-machine?" in: Trends in biochemical sciences, Vol. 27, Issue 7, pp. 327-9, 2002 (PubMed).

Validation Images
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