You are viewing an incomplete version of our website. Please click to reload the website as full version.

CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (Ser33)

Details for Product anti-CTNNB1 Antibody No. ABIN152613, Supplier: Log in to see
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
Alternatives
anti-Human CTNNB1 antibody for Enzyme Immunoassay
Epitope
Ser33, Ser37
99
25
21
20
20
17
15
14
12
7
7
7
7
6
6
5
5
5
5
5
5
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
447
109
96
28
21
13
13
6
5
4
4
2
1
1
1
Host
Rabbit
317
154
2
2
Clonality
Polyclonal
Conjugate
This CTNNB1 antibody is un-conjugated
15
12
9
6
6
6
1
1
Application
Western Blotting (WB)
404
153
116
100
84
66
66
32
16
13
8
4
3
3
2
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33,Ser37 conjugated to KL
Specificity Specific for the ~83k beta-catenin phosphorylated at Ser33 and Ser37.
Cross-Reactivity (Details) Tested in Human. Reactivity assumed based on 100% sequence identity: Mouse, Rat,Xenopus.
Purification Immunogen affinity purified
Alternative Name CTNNB1 / Beta Catenin (CTNNB1 Antibody Abstract)
Background B-Catenin is a central component of the cadherin cell adhesion complex and plays anessential role in neural development in the Wingless/Wnt signaling pathway (Ding andDale, 2002, Polakis, 2000). The role of B-catenin in these processes is thoughtregulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 byglycogen synthase kinase 3B (GSK3B) (Liu et al, 2002). This hyperphosphorylationpromotes the ubiquitylation and targeted destruction of B-catenin. Mutations incomponents of this phosphorylation regulated process that prevent B-cateninhyperphosphorylation by GSK3B are strongly associated with cancers (Wang et al,2003, Polakis, 2000, Liu et al, 2002). Alternate Names: anti-Beta-Catenin antibody, anti-B-Catenin antibody, anti-CTNNB antibody.
Gene Symbol: CTNNB1
Gene ID 1499, 84353
Pathways WNT Signaling
Application Notes Recommended dilutions: Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES [pH 7.5], 150 mM NaCl, 0.1 mg/ml BSA and 50 % glycerol
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
Western Blotting (WB) image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (Ser33) (ABIN152613) Western Blot of human embryonic kidney cell (HEK) lysate showing immunolabeling with ...
Product cited in: Ding, Dale: "Wnt signal transduction: kinase cogs in a nano-machine?" in: Trends in biochemical sciences, Vol. 27, Issue 7, pp. 327-9, 2002 (PubMed).

Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).