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Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) (AA 103-117), (Extracellular Loop) antibody

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Synonyms CFTR, AW495489, Abcc7, RGD1561193, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, abc35, abcc7, cftr/mrp, mrp7, tnr-cftr, xcftr
AA 103-117, Extracellular Loop
(12), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(79), (24), (19), (3), (2), (2), (2), (1), (1)
(44), (31), (5)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB), Blocking Reagent (BR), Neutralization (Neut), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(54), (28), (27), (25), (22), (21), (4), (4), (3), (3), (2), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mL
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Immunogen Synthetic peptide : G(103)RIIASYDPDNKEER(117). Immunizing peptide corresponds to amino acid residues 103-117 found in the first extracellular loop of human and rabbit CFTR. This sequence is highly conserved in mouse, sheep, cow, and Xenopus laevis.
Clone CF3
Isotype IgM
Specificity CFTR (CF3)
Cross-Reactivity (Details) Reported cross-reactivity in rat,(see product references). Not yet tested in other species.
Purification Ascites
Alternative Name ABCC7 / CFTR (CFTR Antibody Abstract)
Background Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of thegene coding for the cystic fibrosis transmembrane conductance factor, a cAMPregulated chloride channel. Approximately 70% of all CF cases share the deletion of aphenylalanine at position 508 (delta F508) which results in abnormal chloride transport.Since the CF mutation is lethal, most often by lung and liver disease, it raises thequestion of why this genetic disease remains as common as it is. One possibleexplanation is that Salmonella typhi has been shown to use CFTR to enter intestinalepithelial cells and that delta F508 heterozygote and homozygote mice showed 86%and 100% reductions in S.typhi intestinal submucosal uptake. Alternate Names: anti-ABC 35 antibody, anti-ABC35 antibody, anti-ABCC 7 antibody, anti-ABCC7antibody, anti-ATP binding cassette sub family C member 7 antibody, anti-ATP BindingCassette Superfamily C Member 7 antibody, anti-ATP binding cassette transporter subfamily C member 7 antibody, anti-cAMP dependent chloride channel antibody, anti-CFantibody, anti-CFTR/MRP antibody, anti-Cystic fibrosis transmembrane conductanceregulator antibody, anti-Cystic Fibrosis Transmembrane Regulator antibody,anti-dJ760C5.1 antibody, anti-MRP 7 antibody, anti-MRP7 antibody, anti-TNR CFTRantibody.
Gene Symbol: CFTR
Gene ID 1080, 12638
Application Notes By Western blot, this antibody detects a single ~170 kDa protein. Immunofluorescence staining of CFTR in mouse epithelial cells results in cell surface staining, consistent with localization at the plasma membrane. This antibody also detects one or more immunologically related proteins in murine cell line Heb7a that does not contain CFTR mRNA. This antibody can also be used to inhibit the epithelial uptake of S. typhi in some mouse cell lines. Flow Cytometry reported in literature (See Product References). Immunocytochemistry reported in literature (See Product References). Blocking Assay reported in literature (See Product References). Immunohistochemistry was reported in scientific literature. Blocking Assay was reported in the scientific literature (PMID: 9590693).
Recommended dilutions: Blocking/Neutralizing, Flow Cytometry 1:10-1:1000, Immunocytochemistry/Immunofluorescence 1:500, Immunohistochemistry 1:200, Immunohistochemistry-Paraffin 1:200, Immunoprecipitation 1:10-1:500, Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Buffer Diluted ascites, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Product cited in: Benlloch, Ortega, Ferrer et al.: "Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6950-9, 2005 (PubMed).

Background publications Pier, Grout, Zaidi et al.: "Salmonella typhi uses CFTR to enter intestinal epithelial cells." in: Nature, Vol. 393, Issue 6680, pp. 79-82, 1998 (PubMed).

Walker, Watson, Holmes et al.: "Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins." in: Journal of cell science, Vol. 108 ( Pt 6), pp. 2433-44, 1995 (PubMed).

Catalog No. ABIN152670
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