Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) antibody

Details for Product No. ABIN152670
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, AW495489, Abcc7, RGD1561193, CFTR
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(74), (26), (24), (14), (14), (12), (12), (1), (1), (1)
Host
Mouse
(41), (32), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(43), (28), (28), (25), (23), (13), (11), (10), (3), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN152670
Quantity 0.1 mL
Price
Contact our Customer Service for availability and price in your country.
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide : G(103)RIIASYDPDNKEER(117). Immunizing peptide correspondsto amino acid residues 103-117 found in the first extracellular loop of human and rabbitCFTR. This sequence is highly conserved in mouse, sheep, cow, and Xenopus laevis.
Clone CF3
Isotype IgM
Specificity Species Reactivity: Cross-reacts with Human and Mouse.Not yet tested in other species. Localization: Membrane, multi-pass membrane protein.
Cross-Reactivity Human, Mouse (Murine)
Purification Ascites
Alternative Name ABCC7 / CFTR
Background Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of thegene coding for the cystic fibrosis transmembrane conductance factor, a cAMPregulated chloride channel. Approximately 70% of all CF cases share the deletion of aphenylalanine at position 508 (delta F508) which results in abnormal chloride transport.Since the CF mutation is lethal, most often by lung and liver disease, it raises thequestion of why this genetic disease remains as common as it is. One possibleexplanation is that Salmonella typhi has been shown to use CFTR to enter intestinalepithelial cells and that delta F508 heterozygote and homozygote mice showed 86%and 100% reductions in S.typhi intestinal submucosal uptake. Alternate Names: anti-ABC 35 antibody, anti-ABC35 antibody, anti-ABCC 7 antibody, anti-ABCC7antibody, anti-ATP binding cassette sub family C member 7 antibody, anti-ATP BindingCassette Superfamily C Member 7 antibody, anti-ATP binding cassette transporter subfamily C member 7 antibody, anti-cAMP dependent chloride channel antibody, anti-CFantibody, anti-CFTR/MRP antibody, anti-Cystic fibrosis transmembrane conductanceregulator antibody, anti-Cystic Fibrosis Transmembrane Regulator antibody,anti-dJ760C5.1 antibody, anti-MRP 7 antibody, anti-MRP7 antibody, anti-TNR CFTRantibody.
Gene ID 1080, 12638
Application Notes Suggested working dilutions: immunofluorescence 1:500,Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Buffer Diluted ascites with sodium azide
Preservative Sodium azide
Storage -20 °C
General Walker, Watson, Holmes et al.: "Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins." in: Journal of cell science, Vol. 108 ( Pt 6), pp. 2433-44, 1995 (PubMed).

Pier, Grout, Zaidi et al.: "Salmonella typhi uses CFTR to enter intestinal epithelial cells." in: Nature, Vol. 393, Issue 6680, pp. 79-82, 1998 (PubMed).

Benlloch, Ortega, Ferrer et al.: "Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6950-9, 2005 (PubMed).

Hosts (41), (32), (3), (1)
Reactivities (74), (26), (24), (14), (14), (12), (12), (1), (1), (1)
Applications (43), (28), (28), (25), (23), (13), (11), (10), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top