DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibody

Details for Product No. ABIN152675
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Antigen
Synonyms ICF, ICF1, M.HsaIIIB, cb91, dnmt3bl, dnmt7, sb:cb91, wu:fb16h07, cb633, dnmt3b, DNMT3B, LOC100218113
Reactivity
Human
(64), (26), (20), (1), (1), (1), (1)
Host
Rabbit
(56), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(53), (20), (17), (16), (12), (12), (10), (8), (7), (3), (2), (2)
Pubmed 1 reference available
Catalog no. ABIN152675
Quantity 0.1 mg
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Immunogen Synthetic peptide: MKGDSRHLNEEEGA-C, corresponding to amino acids 1-14 ofMouse Dnmt3b.
Specificity This antibody detects DNA methyltransferase 3b (Dnmt3b) from human and mousetissues and cells as well as recombinant human Dnmt3b. This antibody detects, to alesser extent, full-length human recombinant Dnmt3a. Species Reactivity: Cross-reacts with Human and Mouse. Not yet tested in other species. Localization: Nuclear.
Cross-Reactivity Human, Mouse (Murine)
Purification Aff - Purified
Alternative Name DNMT3B
Background DNA methyltransferases methylate the 5-position of cytosine in the context of CpGdinucleotides. DNA methylation is crucial for normal embryonic development, geneticimprinting, and X-chromosome inactivation. Hypermethylation of DNA has also beenimplicated in tumorigenesis through improper methylation of growth regulatory genepromoter regions. Alternate Names: anti-ICF antibody, anti-M.HsaIIIB antibodyCytosine 5methyltransferase 3B antibody,anti- DNA (cytosine 5) methyltransferase 3 beta antibody. anti- DNA antibody, anti- DNAmethyltransferase HsaIIIB antibody, anti- EC 2.1.1.37 antibody, anti- ICF antibody, anti-M.HsaIIIB antibody.
Gene ID 1789, 13436
Application Notes Suggested working dilutions: chromatin immunoprecipitation 2ug/106,Western Blot 2.0 ug/ml. Positive Controls: P19 nuclear extracts.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 1 mg/ml BSA
Storage -20 °C
General Okano, Bell, Haber et al.: "DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development." in: Cell, Vol. 99, Issue 3, pp. 247-57, 1999 (PubMed).

Hosts (56), (9), (4)
Reactivities (64), (26), (20), (1), (1), (1), (1)
Applications (53), (20), (17), (16), (12), (12), (10), (8), (7), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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