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Vesicle-Associated Membrane Protein 4 (VAMP4) antibody

Details for Product No. ABIN152692
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Antigen
Synonyms zgc:73166, zgc:86855, VAMP4, vamp4, VAMP-4, VAMP24, D1Ertd147e
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(43), (16), (4)
Host
Rabbit
(43), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(39), (29), (14), (12), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN152692
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Immunogen Recombinant full length protein (Rat)
Specificity VAMP4
Cross-Reactivity (Details) Not yet tested in other species.
Purification affinity purified
Alternative Name VAMP-4
Background The vesicle associated membrane proteins (VAMP) or synaptobrevins are calciumbinding proteins specific to eukaryotes. VAMPs, along with synaptosomal associatedprotein of 25 kDa (SNAP 25) and syntaxin, form the core complex of soluble NSFattachment protein receptor (SNARE) proteins that interact with the soluble proteinsN-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associatedproteins play a key role in the regulation of vesicle membrane fusion with the plasmamembrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity forVAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantlylowered.
Gene Symbol: VAMP4
Gene ID 8674, 53330, 364033
Application Notes Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:10-1:2000, Immunohistochemistry 1:10-1:2000, Immunohistochemistry-Paraffin 1:10-1:2000, Western Blot 1:100-1:2000
Restrictions For Research Use only
Buffer PBS and 1 mg/ml BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
General Kreykenbohm, Wenzel, Antonin et al.: "The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners." in: European journal of cell biology, Vol. 81, Issue 5, pp. 273-80, 2002 (PubMed).

Williams, Pessin: "Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes." in: The Journal of cell biology, Vol. 180, Issue 2, pp. 375-87, 2008 (PubMed).

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