Vesicle-Associated Membrane Protein 4 (VAMP4) antibody

Details for Product No. ABIN152692
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Antigen
Synonyms VAMP-4, VAMP24, D1Ertd147e, zgc:73166, zgc:86855, VAMP4, vamp4
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(29), (15), (7)
Host
Rabbit
(29), (2)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(27), (16), (13), (6), (3), (1)
Pubmed 2 references available
Catalog no. ABIN152692
Quantity 0.1 mg
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Immunogen Recombinant full length protein (Rat).
Specificity Species Reactivity: Cross-reacts with Human, Rat and Mouse.Not yet tested in other species.
Purification Affinity Purified
Alternative Name VAMP-4
Background The vesicle associated membrane proteins (VAMP) or synaptobrevins are calciumbinding proteins specific to eukaryotes. VAMPs, along with synaptosomal associatedprotein of 25 kDa (SNAP 25) and syntaxin, form the core complex of soluble NSFattachment protein receptor (SNARE) proteins that interact with the soluble proteinsN-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associatedproteins play a key role in the regulation of vesicle membrane fusion with the plasmamembrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity forVAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantlylowered.
Gene ID 8674, 53330, 364033
Application Notes Immunofluorescence: use at a concentration of 10
Restrictions For Research Use only
Buffer PBS, 1 mg/ml BSA, 0.05% sodium azide
Preservative Sodium azide
Storage -20 °C
General Kreykenbohm, Wenzel, Antonin et al.: "The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners." in: European journal of cell biology, Vol. 81, Issue 5, pp. 273-80, 2002 (PubMed).

Williams, Pessin: "Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes." in: The Journal of cell biology, Vol. 180, Issue 2, pp. 375-87, 2008 (PubMed).

Hosts (29), (2)
Reactivities (29), (15), (7)
Applications (27), (16), (13), (6), (3), (1)
Epitopes (13), (3), (2), (2), (1), (1)
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