Cannabinoid Receptor 1 (CNR1) (AA 1-99) antibody

Details for Product No. ABIN152711
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Antigen
Synonyms CNR1, LOC540382, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, SKR6R, cnr1-A
Epitope
AA 1-99
(13), (11), (9), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(82), (41), (35), (15), (13), (13), (13), (5), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(71), (10), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(68), (37), (22), (12), (11), (11), (10), (5), (3), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN152711
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Immunogen Fusion protein, corresponding to amino acids 1-99 of Human Cannabinoid Receptor I.
Specificity Detects CB1 from human and rat tissues as well as transfected rat CB1.
Cross-Reactivity (Details) Not yet tested in other species.
Purification affinity purified
Alternative Name Cannabinoid receptor 1
Background Cannabinoids exert their well known physiological effects through two G protein coupledreceptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors havebeen shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated proteinkinase, MAPK. CB1 receptors also modulate ion channels through direct G-proteininteractions. Delta 9-tetrahydrocannibinol and related ligands likely exert theirpsychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2is thought to function primarily in the immune system although it has been suggested tobe present in the central nervous system, including the retina. Alternate Names: anti-CANN6 antibody, anti-CB R antibody, anti-CB1 antibody, anti-CB1A antibody,anti-CB1K5 antibody, anti-Central cannabinoid receptor isoform a antibody, anti-Centralcannabinoid receptor isoform b antibody, anti-CNR antibody.
Gene Symbol: CNR1
Gene ID 1268, 25248
Research Area Receptors
Application Notes Western Blot: use at a dilution of 1:250. Immunocytochemistry: use at a dilution of 1:1000. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects an ~60 kDa protein representing CB1 from rat brain homogenate. Immunocytochemical staining of CB1 in AtT20 cells transfected with the rat CB1 gene yields a pattern consistent with plasma membrane staining.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Western Blot 1:100-1:2000
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 50 % glycerol and 1 mg/ml BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
Supplier Images
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-99) antibody Figure 1 shows immunlocalization of rat CB1 transfected into AtT20 cells using ABIN152711.
General Mulhern, Madson, Danford et al.: "The unfolded protein response in lens epithelial cells from galactosemic rat lenses." in: Investigative ophthalmology & visual science, Vol. 47, Issue 9, pp. 3951-9, 2006 (PubMed).

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