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Details for Product No. ABIN152711

Cannabinoid Receptor 1 (CNR1) antibody

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Antigen
Synonyms CB1, CNR, CB-R, CB1A, CB1R, CANN6, CB1K5, SKR6R, CNR1, LOC540382
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN152711
Quantity 0.1 mL
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Immunogen Fusion protein, corresponding to amino acids 1-99 of Human Cannabinoid Receptor I.
Specificity Detects CB1 from human and rat tissues as well as transfected rat CB1. Species Reactivity: Cross-reacts with Human and Rat.Not yet tested in other species. Localization: Integral membrane protein.
Cross-Reactivity Human, Rat (Rattus)
Purification Affinity Purified
Alternative Name Cannabinoid receptor 1
Background Cannabinoids exert their well known physiological effects through two G protein coupledreceptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors havebeen shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated proteinkinase, MAPK. CB1 receptors also modulate ion channels through direct G-proteininteractions. Delta 9-tetrahydrocannibinol and related ligands likely exert theirpsychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2is thought to function primarily in the immune system although it has been suggested tobe present in the central nervous system, including the retina. Alternate Names: anti-CANN6 antibody, anti-CB R antibody, anti-CB1 antibody, anti-CB1A antibody,anti-CB1K5 antibody, anti-Central cannabinoid receptor isoform a antibody, anti-Centralcannabinoid receptor isoform b antibody, anti-CNR antibody.
Gene ID 1268, 25248
Research Area Receptors
Application Notes Western Blot: use at a dilution of 1:250. Immunocytochemistry: use at a dilution of1:1000. Optimal dilutions / concentrations should be determined by the end user. ByWestern blot, this antibody detects an ~60 kDa protein representing CB1 from rat brainhomogenate. Immunocytochemical staining of CB1 in AtT20 cells transfected with therat CB1 gene yields a pattern consistent with plasma membrane staining.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer PBS, 50% glycerol, 1 mg/ml BSA and 0.05% sodium azide. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage -20 °C
Mulhern, Madson, Danford et al.: "The unfolded protein response in lens epithelial cells from galactosemic rat lenses." in: Investigative ophthalmology & visual science, Vol. 47, Issue 9, pp. 3951-9, 2006 (PubMed).

Alternatives for antigen "Cannabinoid Receptor 1 (CNR1)", type "Antibodies"
Hosts (64), (10), (7)
Reactivities (76), (42), (37), (15), (12), (12), (12), (4), (1), (1), (1), (1), (1)
Applications (60), (32), (24), (13), (11), (10), (10), (4), (1), (1), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (7), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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