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Nuclear Receptor Coactivator 3 (NCOA3) (AA 3-15) antibody

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NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, 2010305B15Rik, AW321064, Actr, Aib1, Rac3, Src3, Tram-1, Tram1, p/Cip, pCip, actr, aib-1, aib ... show more
NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, 2010305B15Rik, AW321064, Actr, Aib1, Rac3, Src3, Tram-1, Tram1, p/Cip, pCip, actr, aib-1, aib1, cagh16, ctg26, kat13b, pcip, rac3, src-3, src3, tnrc14, tnrc16, tram-1, xSRC-3 show less
AA 3-15
(18), (17), (17), (13), (12), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(142), (12), (9), (2), (1)
(91), (48), (5), (1)
(3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(107), (44), (29), (18), (16), (13), (10), (7), (3), (3), (3), (2), (2), (1)
Pubmed 4 references available
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Quantity 0.1 mg
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Immunogen Synthetic peptide: GLGENLDPLASDSC, corresponding to amino acids 3-15 of Human AIB 1.
Specificity Detects amplified in breast cancer 1 (nuclear receptor coactivator 3) from human tissues and cells.
Cross-Reactivity (Details) Expected to cross-react with Xenopus laevis (92% identity with immunogen) due to sequence homology. Not yet tested in other species.
Purification affinity purified
Alternative Name NCOA3 (NCOA3 Antibody Abstract)
Background Steroid and thyroid hormones and retinoic acid regulate a complex array of geneexpression activity via intracellular receptor transcription factors belonging to theligand-dependent nuclear receptor superfamily. Adding to the complexity of function ofthese transcription factors are associated proteins known as coactivators andcorepressors which, as their names suggest, enhance or depress transcription activity ofthe nuclear receptor with which they associate. Amplified in breast cancer-1 (AIB-1), is amember of a growing family of transcriptional coactivator proteins which includes steroidreceptor coactivator-1 (SRC-1) and glucocorticoid receptor interacting protein-1(GRIP1).AIB1/RAC3 has been shown to interact and stimulate transcriptional activity of theretinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone,androgen, progesterone, and peroxisome proliferator activated receptors. AIB1/RAC3also interacts with the transcriptional integrators CREB binding protein (CBP) and p300. Alternate Names: anti-KAT13B / AIB1 antibody, anti-ACTR antibody, anti-AIB 1 antibody, anti-AIB1antibody, anti-Amplified in breast cancer 1 antibody, anti-Amplified in breast cancer 1protein antibody, anti-CAGH 16 antibody, anti-CAGH16 antibody, anti-CBP interactingprotein antibody, anti-CTG 26 antibody, anti-CTG26 antibody, anti-MGC141848antibody, anti-NCOA 3 antibody, anti-NCOA3 antibody, anti-Nuclear receptor coactivator3 antibody, anti-pCIP antibody, anti-RAC 3 antibody, anti-RAC3 antibody, anti-Receptorassociated coactivator 3 antibody, anti-SRC 3 antibody, anti-SRC3 antibody,anti-Steroid receptor coactivator protein 3 antibody, anti-Thyroid hormone receptoractivator molecule 1 antibody, anti-TRAM 1 antibody, anti-TRAM1 antibody.
Gene Symbol: NCOA3
Gene ID 8202
Application Notes Western Blot: Predicted molecular weight: 155 kDa. Can be blocked with < ab4915>AIB 1 peptide Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Buffer PBS, 1 mg/ml BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 3-15) antibody (ABIN152726) anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 3-15) antibody
Product cited in: Heemers, Regan, Schmidt et al.: "Androgen modulation of coregulator expression in prostate cancer cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 4, pp. 572-83, 2009 (PubMed).

Background publications Takeshita, Cardona, Koibuchi et al.: "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1." in: The Journal of biological chemistry, Vol. 272, Issue 44, pp. 27629-34, 1997 (PubMed).

Anzick, Kononen, Walker et al.: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 965-8, 1997 (PubMed).

Li, Gomes, Chen: "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8479-84, 1997 (PubMed).

Catalog No. ABIN152726
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