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Details for Product No. ABIN152726

Nuclear Receptor Coactivator 3 (NCOA3) antibody

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Antigen
Synonyms
ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, Aib1, Tram-1, 2010305B15Rik, AW321064, Actr, Rac3, Src3, Tram1, p/Cip, pCip, actr, aib-1, aib1, cagh ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN152726
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide: GLGENLDPLASDSC, corresponding to amino acids 3-15 of HumanAIB 1.
Specificity Detects amplified in breast cancer 1 (AIB1). Species Reactivity: Cross-reacts with Human.Expected to cross-react with Xenopus laevis (92% identitywith immunogen) due to sequence homology.Not yet tested in other species. Localization: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequentphosphorylation, it translocates from the cytoplasm to the nucleus.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name NCOA3
Background Steroid and thyroid hormones and retinoic acid regulate a complex array of geneexpression activity via intracellular receptor transcription factors belonging to theligand-dependent nuclear receptor superfamily. Adding to the complexity of function ofthese transcription factors are associated proteins known as coactivators andcorepressors which, as their names suggest, enhance or depress transcription activity ofthe nuclear receptor with which they associate. Amplified in breast cancer-1 (AIB-1), is amember of a growing family of transcriptional coactivator proteins which includes steroidreceptor coactivator-1 (SRC-1) and glucocorticoid receptor interacting protein-1(GRIP1).AIB1/RAC3 has been shown to interact and stimulate transcriptional activity of theretinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone,androgen, progesterone, and peroxisome proliferator activated receptors. AIB1/RAC3also interacts with the transcriptional integrators CREB binding protein (CBP) and p300. Alternate Names: anti-KAT13B / AIB1 antibody, anti-ACTR antibody, anti-AIB 1 antibody, anti-AIB1antibody, anti-Amplified in breast cancer 1 antibody, anti-Amplified in breast cancer 1protein antibody, anti-CAGH 16 antibody, anti-CAGH16 antibody, anti-CBP interactingprotein antibody, anti-CTG 26 antibody, anti-CTG26 antibody, anti-MGC141848antibody, anti-NCOA 3 antibody, anti-NCOA3 antibody, anti-Nuclear receptor coactivator3 antibody, anti-pCIP antibody, anti-RAC 3 antibody, anti-RAC3 antibody, anti-Receptorassociated coactivator 3 antibody, anti-SRC 3 antibody, anti-SRC3 antibody,anti-Steroid receptor coactivator protein 3 antibody, anti-Thyroid hormone receptoractivator molecule 1 antibody, anti-TRAM 1 antibody, anti-TRAM1 antibody.
Gene ID 116833
Application Notes Suggested working dilutions: Western Blot 2 ug/ml
Restrictions For Research Use only
Buffer PBS, 1 mg/ml BSA. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage -20 °C
Li, Gomes, Chen: "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8479-84, 1997 (PubMed).

Anzick, Kononen, Walker et al.: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 965-8, 1997 (PubMed).

Takeshita, Cardona, Koibuchi et al.: "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1." in: The Journal of biological chemistry, Vol. 272, Issue 44, pp. 27629-34, 1997 (PubMed).

Heemers, Regan, Schmidt et al.: "Androgen modulation of coregulator expression in prostate cancer cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 4, pp. 572-83, 2009 (PubMed).

Alternatives for antigen "Nuclear Receptor Coactivator 3 (NCOA3)", type "Antibodies"
Hosts (66), (35), (3)
Reactivities (103), (19), (13), (12), (12), (12), (12), (12), (2)
Applications (69), (30), (20), (20), (15), (8), (3), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (10), (7), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
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