phosphodiesterase 4A, CAMP-Specific (PDE4A) (C-Term) antibody

Details for Product No. ABIN152828
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Synonyms pde4, dpde2, pde46, PDE4A, Pde4a, D9Ertd60e, Dpde2, DPDE2, PDE4, PDE46, PHOSA
(21), (15), (8), (3), (2), (2), (2), (1), (1), (1)
Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus)
(82), (27), (25), (3), (2), (2)
(64), (26)
(7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
(68), (29), (24), (23), (20), (15), (13), (12), (10), (3), (3), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide corresponding to the C-terminal region of PDE4A (common to all PDE4A proteins).
Specificity This labels all known PDE4A variants including PDE4A1 (66 kDa), A5 (109 kDa), A8 (106 kDa), Ax (102 kDa) and a 76 kDa testis specific A variant.
Purification Affinity purified
Alternative Name PDE4A (PDE4A Antibody Abstract)
Background Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family areimportant in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR)stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by thestimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are alsoimportant molecular targets for a variety of therapeutic agents like antidepressants,anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprises 4 genes (PDE4A,B, C and D), each exhibiting multiple isozymes due to alternate splicing that leads to alarger number of distinct PDE4 variants. Members of the PDE4 family areregulated/activated by phosphorylation/dephosphorylation by cAMP-dependent proteinkinase A and phosphatases. Protein-protein interactions and cellular trafficking ofPDE4A enzymes play an important role in cAMP compartmentalization andcAMP-dependent signaling. In brain members of the PDE4A, B and D family areassociated with GPCRs (adrenergic and dopaminergic) signaling. Alternate Names: Anti-cAMP specific 3 5 cyclic phosphodiesterase 4A antibody, anti- cAMP specific phosphodiesterase antibody, anti- Cyclic AMP phosphodiesterasePDE4A11 antibody, anti- Cyclic AMP specific phosphodiesterase HSPDE4A10 antibody,anti- DPDE 2 antibody, anti- dunce like phosphodiesterase E2 antibody, anti- PDE 4antibody.
Gene Symbol: PDE4A
Gene ID 5141, 18577, 25638
Research Area Signaling
Application Notes Detects bands at 66 kDa (PDE4A1), 109 kDa (PDE4A5), 106 kDa(PDE4A8), 102 kDa (PDE4Ax) and 76 kDa (testis specific PDE4A variant).
Recommended dilutions: Immunoprecipitation 1:10-1:500, Western Blot 1:100-1:2000, Immunocytochemistry/Immunofluorescence 1:10-1:2000
Restrictions For Research Use only
Concentration 1.0 mg/mL
Preservative Thimerosal (Merthiolate)
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (C-Term) antibody (ABIN152828) anti-phosphodiesterase 4A, CAMP-Specific (PDE4A) (C-Term) antibody
Product cited in: Hagendorf, Fluegge, Engelhardt et al.: "Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 1, pp. 206-21, 2009 (PubMed).

Zhang, Crissman, Dorairaj et al.: "Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 23, Issue 2, pp. 198-204, 2000 (PubMed).

Background publications Yarwood, Steele, Scotland et al.: "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14909-17, 1999 (PubMed).

Beavo: "Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms." in: Physiological reviews, Vol. 75, Issue 4, pp. 725-48, 1995 (PubMed).

Farooqui, Brock, Hamdi et al.: "Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum." in: Journal of neurochemistry, Vol. 57, Issue 4, pp. 1363-9, 1991 (PubMed).

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Catalog No. ABIN152828
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